Vercelli Cristina, Re Giovanni, Iussich Selina, Odore Rosangela, Morello Emanuela Maria, Gandini Marco, Giusto Gessica
Department of Veterinary Sciences, University of Turin, Largo Paolo Braccini, N. 2, Grugliasco, 10095 Turin, Italy.
Gels. 2021 Aug 31;7(3):132. doi: 10.3390/gels7030132.
Investigations about ventral hernia repair are focused on improving the quality, resistance, and biocompatibility of mesh. This study compared plain polypropylene mesh with a pectin-honey hydrogel-coated polypropylene mesh in an acute hernia model in rats. Forty Wistar rats, randomly assigned to two groups, were submitted to laparotomy, and a 1 cm × 2 cm fascial defect was created, centered on the midline. Uncoated (group C) or coated mesh (group T) was inserted in an inlay fashion to repair the defect. After 30 days, the rats were euthanized, and the presence of adhesions to the mesh was macroscopically evaluated. Histology and measurement of COX-2 as tissue inflammation markers were used to assess fascia tissue healing. Grades of adhesion were not different between groups. Histological score and COX-2 expression were not significantly different between groups, except for the higher inflammatory response demonstrated in group T. The pectin-hydrogel coated mesh could not reduce adhesion formation compared to uncoated polypropylene mesh but improved peritoneal regeneration and tissue healing.
关于腹疝修补的研究主要集中在提高补片的质量、抗张强度和生物相容性上。本研究在大鼠急性疝模型中，将普通聚丙烯补片与果胶-蜂蜜水凝胶涂层聚丙烯补片进行了比较。40只Wistar大鼠随机分为两组，接受剖腹手术，并在中线处制造一个1cm×2cm的筋膜缺损。未涂层（C组）或涂层补片（T组）以镶嵌方式插入以修复缺损。30天后，对大鼠实施安乐死，并通过肉眼评估补片粘连情况。采用组织学和测量COX-2作为组织炎症标志物来评估筋膜组织愈合情况。两组之间的粘连分级没有差异。除T组显示出较高的炎症反应外，两组之间的组织学评分和COX-2表达没有显著差异。与未涂层的聚丙烯补片相比，果胶-水凝胶涂层补片不能减少粘连形成，但能改善腹膜再生和组织愈合。
