Niedźwiedź A, Jaworski Z, Kubiak K
Pol J Vet Sci. 2014;17(4):697-702. doi: 10.2478/pjvs-2014-0101.
The aim of this study was to investigate the levels of circulating immune complexes (CICs) and concentration of haptoglobin, fibrinogen and C-reactive protein in the serum of horses with recurrent airway obstruction and healthy controls. The study was conducted on a group of 14 adult Polish Konik horses, kept in uniform environmental and living conditions. Horses were divided into two groups: 7 horses were not affected by any respiratory problem (control group) and 7 horses had a history of recurrent airway obstruction (RAO) (study group). A clinical and laboratory evaluation, endoscopic examination and bronchoalveolar lavage (BAL) were performed in all horses. Levels of circulating immune complexes were significantly (p = 0.0057) increased in heaves-affected horses compared to healthy controls (median [25th-75th percentiles]) (3.96 [3.96-4.43] vs. 7.46 [5.13-11.9]). No significant difference was observed in the levels of the examined acute phase proteins between the groups. Moreover, all results were within the reference range established for horses. The results of this study indicate that heaves in horses is associated with the formation and high level of CICs. Haptoglobin, fibrinogen and C-reactive protein failed as markers of early stage systemic inflammation in the course of RAO.
本研究的目的是调查复发性气道阻塞马匹和健康对照血清中循环免疫复合物（CICs）水平以及触珠蛋白、纤维蛋白原和C反应蛋白的浓度。研究在一组14匹成年波兰科尼克马中进行，它们饲养在统一的环境和生活条件下。马匹被分为两组：7匹马未受任何呼吸问题影响（对照组），7匹马有复发性气道阻塞（RAO）病史（研究组）。对所有马匹进行了临床和实验室评估、内镜检查及支气管肺泡灌洗（BAL）。与健康对照相比，气喘病马匹的循环免疫复合物水平显著升高（p = 0.0057）（中位数[第２５-７５百分位数]）（3.96 [3.96 - 4.43] 对比 7.46 [5.13 - 11.9]）。两组间所检测的急性期蛋白水平未观察到显著差异。此外，所有结果均在为马匹确定的参考范围内。本研究结果表明，马匹气喘病与CICs的形成及高水平有关。在RAO病程中，触珠蛋白、纤维蛋白原和C反应蛋白未能作为早期全身炎症的标志物。
