D-氨基酸氧化酶在小鼠体内游离D-氨基酸清除过程中的作用。
Involvement of D-amino acid oxidase in elimination of free D-amino acids in mice.
作者信息
Nagata Y, Konno R, Yasumura Y, Akino T
机构信息
Department of Biochemistry, Sapporo Medical College, Japan.
出版信息
Biochem J. 1989 Jan 1;257(1):291-2. doi: 10.1042/bj2570291.
Abstract
The physiological role of D-amino acid oxidase was investigated by using mutant ddY/DAO- mice lacking the enzyme. Free D-amino acid concentrations in the mutant mice were significantly higher than those of control ddY/DAO+ mice in kidney, liver, lung, heart, brain, erythrocytes, serum and urine. The results suggest that the enzyme is involved in the catabolism of free D-amino acids in the body, and that free D-amino acids are also excreted into urine.
摘要
通过使用缺乏该酶的ddY/DAO-突变小鼠，对D-氨基酸氧化酶的生理作用进行了研究。突变小鼠肾脏、肝脏、肺、心脏、大脑、红细胞、血清和尿液中的游离D-氨基酸浓度显著高于对照ddY/DAO+小鼠。结果表明，该酶参与体内游离D-氨基酸的分解代谢，且游离D-氨基酸也会排泄到尿液中。
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