Lozano-Carrascal Naroa, Delgado-Ruiz Rafael Arcesio, Gargallo-Albiol Jordi, Maté-Sánchez José Eduardo, Hernandez Alfaro Federico, Calvo-Guirado José Luis
General Dentistry, International University of Catalonia, Barcelona, Spain.
Department of Prosthodontics and Digital Technology, School of Dental Medicine, Stony Brook University, Stony Brook, NY, USA.
Clin Oral Implants Res. 2016 Feb;27(2):149-55. doi: 10.1111/clr.12550. Epub 2015 Jan 30.
The aim of the study was to compare the effects of porcine xenografts (MP3(®)) with or without pamindronate for the healing of small and large defects of postextraction sockets.
Six beagle dogs were used in the study; second premolars and first molars of the mandible were extracted, small defects (SD) and large defects (LD) were identified. Each defect was measured and randomly filled as follows: SC (small control defects filled with MP3(®) alone), ST (small test defects filled with MP3(®) modified with pamindronate), LC (large control defects filled with MP3(®) alone), LT (large test defects filled with MP3(®) modified with pamindronate). After 4 and 8 weeks, the animals were euthanized and the percentages of new bone formation (NB), residual graft (RG) and connective tissue (CT) were analysed by histology and histomorphometry of undecalcified samples.
After 4 weeks, NB formation was higher for ST compared to all groups and for LT compared to LC (P < 0.05); RG was significantly higher in both control groups compared to tests (P < 0.05); and CT was higher in large defects (LC and LT) compared to small defects. After 8 weeks, NB formation was higher for test groups (ST and LT) compared to controls (P < 0.05); RG was significantly higher in both control groups compared to tests (P < 0.05); and CT was higher in large defects (LC and LT) compared to small defects (P < 0.05).
Within the limitations of this experimental study, the findings suggest that porcine xenografts modified with pamindronate favours the new bone formation and increased the porcine xenograft substitution/replacement after 4 and 8 weeks of healing.
本研究旨在比较添加或不添加帕米膦酸盐的猪异种移植物（MP3(®)）对拔牙后牙槽窝小、大骨缺损愈合的影响。
本研究使用6只比格犬；拔除下颌第二前磨牙和第一磨牙，确定小骨缺损（SD）和大骨缺损（LD）。测量每个缺损，并随机填充如下：SC（仅用MP3(®)填充的小对照缺损），ST（用帕米膦酸盐修饰的MP3(®)填充的小试验缺损），LC（仅用MP3(®)填充的大对照缺损），LT（用帕米膦酸盐修饰的MP3(®)填充的大试验缺损）。4周和8周后，对动物实施安乐死，并通过未脱钙样本的组织学和组织形态计量学分析新骨形成（NB）、残余移植物（RG）和结缔组织（CT）的百分比。
4周后，ST组的NB形成高于所有组，LT组的NB形成高于LC组（P < 0.05）；两个对照组的RG均显著高于试验组（P < 0.05）；大骨缺损（LC和LT）的CT高于小骨缺损。8周后，试验组（ST和LT）的NB形成高于对照组（P < 0.05）；两个对照组的RG均显著高于试验组（P < 0.05）；大骨缺损（LC和LT）的CT高于小骨缺损（P < 0.05）。
在本实验研究的局限性范围内，研究结果表明，用帕米膦酸盐修饰的猪异种移植物有利于新骨形成，并在愈合4周和8周后增加了猪异种移植物的替代/替换。
