双膦酸盐局部应用是否能改善口腔种植学中的骨形成？一项系统评价。
Do topical applications of bisphosphonates improve bone formation in oral implantology? A systematic review.
作者信息
Lozano-Carrascal N, Salomó-Coll O, Hernández-Alfaro F, Gehrke S-A, Gargallo-Albiol J, Calvo-Guirado J-L
机构信息
Faculty of Medicine and Dentistry, Universitat Internacional de Catalunya, Carrer de Josep Trueta s/n, 08195 Sant Cugat del Vallés Barcelona, Spain,
出版信息
Med Oral Patol Oral Cir Bucal. 2017 Jul 1;22(4):e512-e519. doi: 10.4317/medoral.21887.
BACKGROUND
The aim of this systematic literature review was to evaluate the feasibility of topical bisphosphonate application for preserving/enhancing alveolar bone in oral implantology.
MATERIAL AND METHODS
An electronic search was conducted in the PubMed/Medline, EMBASE, Scopus, Web of knowledge, and Google-Scholar databases for articles dated from January 2000 to December 2016. Two reviewers assessed the quality of the studies independently.
RESULTS
A total of 154 abstracts were identified, of which 18 potentially relevant articles were selected; a final total of nine papers were included for analysis. Comparison of the findings of the selected studies was made difficult by the heterogeneity of the articles, all of them animal research papers that showed heterogeneity in the methodologies used and a high or moderate risk of bias.
CONCLUSIONS
The topical application of bisphosphonate solution would appear to favor new bone formation in alveolar defects, and boosts the regenerative capacities of biomaterials resulting in increased bone density.
背景
本系统文献综述的目的是评估在口腔种植学中局部应用双膦酸盐以保留/增强牙槽骨的可行性。
材料与方法
在PubMed/Medline、EMBASE、Scopus、Web of knowledge和谷歌学术数据库中进行电子检索，检索2000年1月至2016年12月期间发表的文章。两名评审员独立评估研究质量。
结果
共识别出154篇摘要，其中筛选出18篇可能相关的文章；最终纳入9篇论文进行分析。由于文章的异质性，所选研究结果的比较存在困难，所有文章均为动物研究论文，在所用方法上存在异质性，且存在高或中度偏倚风险。
结论
双膦酸盐溶液的局部应用似乎有利于牙槽骨缺损处的新骨形成，并增强生物材料的再生能力，从而提高骨密度。
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