用于捕获和选择性释放活循环肿瘤细胞的可调谐纳米结构涂层。
Tunable nanostructured coating for the capture and selective release of viable circulating tumor cells.
作者信息
Reátegui Eduardo, Aceto Nicola, Lim Eugene J, Sullivan James P, Jensen Anne E, Zeinali Mahnaz, Martel Joseph M, Aranyosi Alexander J, Li Wei, Castleberry Steven, Bardia Aditya, Sequist Lecia V, Haber Daniel A, Maheswaran Shyamala, Hammond Paula T, Toner Mehmet, Stott Shannon L
机构信息
Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Building 114, 16th Street, Charlestown, MA, 02129, USA; Shriners Hospital for Children, Harvard Medical School, 51 Blossom Street, Boston, MA, 02114, USA; Department of Surgery, Massachusetts General Hospital, Harvard Medical School 55, 55 Fruit Street, Boston, MA, 02114, USA.
出版信息
Adv Mater. 2015 Mar 4;27(9):1593-9. doi: 10.1002/adma.201404677. Epub 2015 Jan 15.
Abstract
A layer-by-layer gelatin nanocoating is presented for use as a tunable, dual response biomaterial for the capture and release of circulating tumor cells (CTCs) from cancer patient blood. The entire nanocoating can be dissolved from the surface of microfluidic devices through biologically compatible temperature shifts. Alternatively, individual CTCs can be released through locally applied mechanical stress.
摘要
本文提出了一种逐层明胶纳米涂层，用作一种可调节的双响应生物材料，用于从癌症患者血液中捕获和释放循环肿瘤细胞（CTC）。通过生物相容性温度变化，整个纳米涂层可从微流控装置表面溶解。或者，可通过局部施加机械应力释放单个CTC。
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