Dworkin Robert H, Turk Dennis C, Trudeau Jeremiah J, Benson Carmela, Biondi David M, Katz Nathaniel P, Kim Myoung
Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, New York; Department of Neurology, University of Rochester School of Medicine and Dentistry, Rochester, New York; Center for Human Experimental Therapeutics, University of Rochester School of Medicine and Dentistry, Rochester, New York.
Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, Washington.
J Pain. 2015 Apr;16(4):357-66. doi: 10.1016/j.jpain.2015.01.012. Epub 2015 Jan 29.
The Short-form McGill Pain Questionnaire (SF-MPQ-2) assesses the major symptoms of both neuropathic and nonneuropathic pain and can be used in studies of epidemiology, natural history, pathophysiologic mechanisms, and treatment response. Previous research has demonstrated its reliability, validity, and responsiveness in diverse samples of patients with chronic pain. However, the SF-MPQ-2 has not been evaluated for use in patients with acute pain. Data were examined from a double-blind, randomized clinical trial of immediate-release tapentadol versus immediate-release oxycodone in patients with acute low back and associated radicular leg pain (N = 666). Analyses of internal consistency, convergent validity, and confirmatory factor structure were conducted using baseline data, and analyses of responsiveness were conducted using baseline and endpoint data. The SF-MPQ-2 total score and its 4 subscale scores (continuous pain, intermittent pain, predominantly neuropathic pain, and affective descriptors) generally showed good psychometric properties and 1) were internally consistent, 2) displayed good convergent validity, 3) fit the a priori factor structure, and 4) were highly responsive to analgesic treatment. These data extend previous evidence of the reliability, validity, and responsiveness of the SF-MPQ-2 in patients with chronic pain to those with acute low back and associated radicular leg pain.
Considered together with the results of other recent studies, the data suggest that the SF-MPQ-2 can provide a valid, responsive, and efficient assessment of both neuropathic and nonneuropathic pain qualities for clinical trials and other clinical research examining patients with various acute and chronic pain conditions.
简版麦吉尔疼痛问卷（SF-MPQ-2）评估神经性疼痛和非神经性疼痛的主要症状，可用于流行病学、自然史、病理生理机制及治疗反应的研究。既往研究已证实其在慢性疼痛患者的不同样本中的可靠性、有效性及反应性。然而，SF-MPQ-2尚未在急性疼痛患者中进行评估。数据来自一项关于速释型曲马多与速释型羟考酮治疗急性下腰痛伴神经根性腿痛患者的双盲、随机临床试验（N = 666）。使用基线数据进行内部一致性、收敛效度及验证性因素结构分析，使用基线和终点数据进行反应性分析。SF-MPQ-2总分及其4个分量表得分（持续性疼痛、间歇性疼痛、主要为神经性疼痛及情感描述）总体显示出良好的心理测量学特性，且1）内部一致，2）显示出良好的收敛效度，3）符合先验因素结构，4）对镇痛治疗反应高度敏感。这些数据将SF-MPQ-2在慢性疼痛患者中的可靠性、有效性及反应性的既往证据扩展至急性下腰痛伴神经根性腿痛患者。
结合其他近期研究结果来看，这些数据表明，对于临床试验及其他针对各种急慢性疼痛患者的临床研究，SF-MPQ-2能够对神经性和非神经性疼痛性质提供有效、敏感且高效的评估。
