Water Jorrit Jeroen, Bohr Adam, Boetker Johan, Aho Johanna, Sandler Niklas, Nielsen Hanne Mørck, Rantanen Jukka
Section for Biologics, Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, 2100, Denmark.
J Pharm Sci. 2015 Mar;104(3):1099-107. doi: 10.1002/jps.24305. Epub 2015 Jan 15.
The aim of the present work was to investigate the potential of three-dimensional (3D) printing as a manufacturing method for products intended for personalized treatments by exploring the production of novel polylactide-based feedstock materials for 3D printing purposes. Nitrofurantoin (NF) and hydroxyapatite (HA) were successfully mixed and extruded with up to 30% drug load with and without addition of 5% HA in polylactide strands, which were subsequently 3D-printed into model disc geometries (10 × 2 mm). X-ray powder diffraction analysis showed that NF maintained its anhydrate solid form during the processing. Release of NF from the disks was dependent on the drug loading in a concentration-dependent manner as a higher level of released drug was observed from disks with higher drug loads. Disks with 30% drug loading were able to prevent surface-associated and planktonic growth of Staphylococcus aureus over a period of 7 days. At 10% drug loading, the disks did not inhibit planktonic growth, but still inhibited surface-associated growth. Elemental analysis indicated the presence of microdomains of solid drug supporting the observed slow and partial drug release. This work demonstrates the potential of custom-made, drug-loaded feedstock materials for 3D printing of pharmaceutical products for controlled release.
本研究的目的是通过探索用于3D打印目的的新型聚丙交酯基原料的生产，研究三维（3D）打印作为一种制造用于个性化治疗产品的方法的潜力。将呋喃妥因（NF）和羟基磷灰石（HA）成功混合并挤出，在聚丙交酯丝中药物负载量高达30%，添加或不添加5%的HA，随后将其3D打印成模型圆盘几何形状（10×2毫米）。X射线粉末衍射分析表明，NF在加工过程中保持其无水固体形式。NF从圆盘中的释放取决于药物负载量，呈浓度依赖性，因为从药物负载量较高的圆盘中观察到较高水平的药物释放。药物负载量为30%的圆盘能够在7天内防止金黄色葡萄球菌的表面相关生长和浮游生长。在药物负载量为10%时，圆盘不抑制浮游生长，但仍抑制表面相关生长。元素分析表明存在固体药物微区，支持观察到的缓慢和部分药物释放。这项工作证明了定制的、载药原料用于3D打印控释药品的潜力。
