耐甲氧西林金黄色葡萄球菌的全球抗生素耐药性
World-wide antibiotic resistance in methicillin-resistant Staphylococcus aureus.
作者信息
Maple P A, Hamilton-Miller J M, Brumfitt W
机构信息
Department of Medical Microbiology, Royal Free Hospital School of Medicine, London.
出版信息
Lancet. 1989 Mar 11;1(8637):537-40. doi: 10.1016/s0140-6736(89)90076-7.
Antibiotic resistance patterns were determined for 106 strains of methicillin-resistant Staphylococcus aureus (MRSA) from 21 countries. Resistance to gentamicin, tobramycin, netilmicin, amikacin, streptomycin, or erthromycin was recorded in more than 90% of strains. Resistance to the other compounds tested was as follows: tetracycline 86%, minocycline 76%, trimethoprim 69%, clindamycin 66%, neomycin 59%, chloramphenicol 39%, rifampicin 26%, fosfomycin 22%, ciprofloxacin 17%, fusidic acid 12%, bacitracin 2%, and novobiocin 1%. All the stains were sensitive to mupirocin, pristinamycin, ramoplanin, teicoplanin, and vancomycin. There were geographical patterns of resistance: MRSA from the UK and Australia were predominantly resistant to trimethoprim, whereas many strains from centres in Europe and the USA were sensitive. MRSA that were resistant to ciprofloxacin were of French and German origin. 15 strains, 12 of which came from France, Turkey, or Brazil, were resistant either to thirteen or to fourteen agents.
对来自21个国家的106株耐甲氧西林金黄色葡萄球菌（MRSA）进行了抗生素耐药模式测定。超过90%的菌株对庆大霉素、妥布霉素、奈替米星、阿米卡星、链霉素或红霉素耐药。对其他测试化合物的耐药情况如下：四环素86%、米诺环素76%、甲氧苄啶69%、克林霉素66%、新霉素59%、氯霉素39%、利福平26%、磷霉素22%、环丙沙星17%、夫西地酸12%、杆菌肽2%、新生霉素1%。所有菌株对莫匹罗星、 pristinamycin、雷莫拉宁、替考拉宁和万古霉素敏感。存在耐药的地理模式：来自英国和澳大利亚的MRSA主要对甲氧苄啶耐药，而来自欧洲和美国一些中心的许多菌株敏感。对环丙沙星耐药的MRSA来自法国和德国。15株菌株，其中12株来自法国、土耳其或巴西，对13种或14种药物耐药。
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