Department of Dermatology, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul, 110-744, South Korea.
Acne and Rosacea Research Laboratory, Seoul National University Hospital, Seoul, South Korea.
Br J Dermatol. 2015 Jul;172 Suppl 1:13-9. doi: 10.1111/bjd.13634.
There are four central factors that contribute to acne physiopathology: the inflammatory response, colonization with Propionibacterium acnes, increased sebum production and hypercornification of the pilosebaceous duct. In addition, research in the areas of diet and nutrition, genetics and oxidative stress is also yielding some interesting insights into the development of acne. In this paper we review some of the most recent research and novel concepts revealed in this work, which has been published by researchers from diverse academic disciplines including dermatology, immunology, microbiology and endocrinology. We discuss the implications of their findings (particularly in terms of opportunities to develop new therapies), highlight interrelationships between these novel factors that could contribute to the pathology of acne, and indicate where gaps in our understanding still exist.
炎症反应、痤疮丙酸杆菌定植、皮脂分泌增加和毛囊皮脂腺导管角化过度。此外，饮食和营养、遗传和氧化应激等领域的研究也为痤疮的发病机制提供了一些有趣的见解。本文综述了一些来自皮肤科、免疫学、微生物学和内分泌学等不同学术领域的研究人员在这一领域发表的最新研究和新的概念。我们讨论了他们的研究结果的意义（特别是在开发新疗法方面的机会），强调了这些新的因素之间的相互关系，这些关系可能有助于痤疮的发病机制，并指出了我们目前理解上仍存在的空白。
