Lee Dong Soo, Im Hyung-Jun, Lee Yun-Sang
Department of Nuclear Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea; Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, Republic of Korea.
Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, Republic of Korea.
Nanomedicine. 2015 May;11(4):795-810. doi: 10.1016/j.nano.2014.12.010. Epub 2015 Jan 30.
Despite of promising preclinical results in the fields of in vivo theragnostics of nanomedicine, a majority of attempt for clinical translation has been blocked by unsolved concerns about possible hazards to human body. Theragnosis of nanomedicine relies on the property of huge surface area to volume ratio of nanomaterials, which can offer potential for multi-functionality. Radionanomedicine has a hybrid characteristic of tracer technology and multi-functionality. Thus, key advantage of radionanomedicine is a possibility of using low amount of nanomaterials for theragnosis. This review article focuses on the concept and advantages of radionanomedicine in theragnosis, formulation of radionanomaterials (particularly encapsulation method), in vivo biodistribution and excretion of radionanomaterials, and immune responses to radionanomaterials.
The expansion of nanomedicine has recently seen the development of a new branch - radionanomedicine. The core concept of radionanomedicine relies on the labeling of radionuclides onto nanomaterials for use both in diagnosis and therapy. In this article, the authors gave a comprehensive review on the current status of radionanomedicine. This should provide interesting reading for practicing clinicians.
尽管纳米医学在体内诊疗领域的临床前研究结果很有前景，但大多数临床转化尝试都因对人体可能危害的未解决担忧而受阻。纳米医学的诊疗依赖于纳米材料巨大的表面积与体积比特性，这可为多功能性提供潜力。放射性纳米医学具有示踪技术和多功能性的混合特征。因此，放射性纳米医学的关键优势在于有可能使用少量纳米材料进行诊疗。本文综述聚焦于放射性纳米医学在诊疗中的概念与优势、放射性纳米材料的制剂（尤其是包封方法）、放射性纳米材料在体内的生物分布与排泄，以及对放射性纳米材料的免疫反应。
纳米医学的扩展最近见证了一个新分支——放射性纳米医学的发展。放射性纳米医学的核心概念依赖于将放射性核素标记到纳米材料上，用于诊断和治疗。在本文中，作者对放射性纳米医学的现状进行了全面综述。这应该会为临床医生提供有趣的阅读内容。
