Gendelman Howard E, Anantharam Vellareddy, Bronich Tatiana, Ghaisas Shivani, Jin Huajun, Kanthasamy Anumantha G, Liu Xinming, McMillan JoEllyn, Mosley R Lee, Narasimhan Balaji, Mallapragada Surya K
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
Department of Biomedical Sciences, Iowa State University, Ames, IA USA.
Nanomedicine. 2015 Apr;11(3):751-67. doi: 10.1016/j.nano.2014.12.014. Epub 2015 Jan 31.
Interest in nanoneuromedicine has grown rapidly due to the immediate need for improved biomarkers and therapies for psychiatric, developmental, traumatic, inflammatory, infectious and degenerative nervous system disorders. These, in whole or in part, are a significant societal burden due to growth in numbers of affected people and in disease severity. Lost productivity of the patient and his or her caregiver, and the emotional and financial burden cannot be overstated. The need for improved health care, treatment and diagnostics is immediate. A means to such an end is nanotechnology. Indeed, recent developments of health-care enabling nanotechnologies and nanomedicines range from biomarker discovery including neuroimaging to therapeutic applications for degenerative, inflammatory and infectious disorders of the nervous system. This review focuses on the current and future potential of the field to positively affect clinical outcomes. From the clinical editor: Many nervous system disorders remain unresolved clinical problems. In many cases, drug agents simply cannot cross the blood-brain barrier (BBB) into the nervous system. The advent of nanomedicines can enhance the delivery of biologically active molecules for targeted therapy and imaging. This review focused on the use of nanotechnology for degenerative, inflammatory, and infectious diseases in the nervous system.
由于迫切需要为精神、发育、创伤、炎症、感染和退行性神经系统疾病开发更好的生物标志物和治疗方法，对纳米神经医学的兴趣迅速增长。由于受影响人数的增加和疾病严重程度的加剧，这些疾病全部或部分构成了重大的社会负担。患者及其护理人员生产力的丧失以及情感和经济负担再怎么强调都不为过。对改善医疗保健、治疗和诊断的需求迫在眉睫。实现这一目标的一个手段是纳米技术。事实上，近年来，有助于医疗保健的纳米技术和纳米药物的发展范围广泛，从包括神经成像在内的生物标志物发现到针对神经系统退行性、炎症性和感染性疾病的治疗应用。本综述重点关注该领域当前和未来对改善临床结果的潜力。临床编辑评论：许多神经系统疾病仍然是尚未解决的临床问题。在许多情况下，药物根本无法穿过血脑屏障进入神经系统。纳米药物的出现可以增强生物活性分子的递送，用于靶向治疗和成像。本综述重点关注纳米技术在神经系统退行性、炎症性和感染性疾病中的应用。
