State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences , 1295 Ding-xi Road, Shanghai, 200050, China.
ACS Appl Mater Interfaces. 2015 Mar 4;7(8):4579-88. doi: 10.1021/am507443p. Epub 2015 Feb 23.
Hollow mesoporous nanomaterials have gained tremendous attention in the fields of nanomedicine and nanobiotechnology. Herein, n-perfluoropentane (PFP)-encapsulated hollow mesoporous Prussian blue (HPB) nanocubes (HPB-PFP) with excellent colloidal stability have been synthesized for concurrent in vivo tumor diagnosis and regression. The HPB shell shows excellent photothermal conversion efficiency that can absorb near-infrared (NIR) laser light and convert it into heat. The generated heat can not only cause tumor ablation by raising the temperature of tumor tissue but also promote the continuous gasification and bubbling of encapsulated liquid PFP with low boiling point. These formed PFP bubbles can cause tissue impedance mismatch, thus apparently enhancing the signal of B-mode ultrasound imaging in vitro and generating an apparent echogenicity signal for tumor tissues of nude mice in vivo. Without showing observable in vitro and in vivo cytotoxicity, the designed biocompatible HPB-PFP nanotheranostics with high colloidal stability and photothermal efficiency are anticipated to find various biomedical applications in activated ultrasound imaging-guided tumor detection and therapy.
中空介孔纳米材料在纳米医学和纳米生物技术领域引起了极大的关注。在此，我们合成了具有优异胶体稳定性的负载全氟戊烷（PFP）的中空介孔普鲁士蓝（HPB）纳米立方（HPB-PFP），用于同时进行体内肿瘤诊断和消退。HPB 壳表现出优异的光热转换效率，能够吸收近红外（NIR）激光并将其转化为热量。产生的热量不仅可以通过提高肿瘤组织的温度来引起肿瘤消融，还可以促进封装的低沸点液体 PFP 的连续气化和冒泡。这些形成的 PFP 气泡会引起组织阻抗失配，从而明显增强体外 B 型超声成像的信号，并在体内产生裸鼠肿瘤组织的明显超声增强效应。所设计的具有高胶体稳定性和光热效率的生物相容性 HPB-PFP 纳米诊疗剂在体外和体内均没有观察到可观察的细胞毒性，预计将在激活超声成像引导的肿瘤检测和治疗中找到各种生物医学应用。
