用于调节心脏病中线粒体动力学和线粒体自噬的新型疗法。

Disatnik Marie-Hélène, Hwang Sunhee, Ferreira Julio C B, Mochly-Rosen Daria

Department of Chemical and Systems Biology, Stanford University School of Medicine, Stanford, CA, 94305, USA.

J Mol Med (Berl). 2015 Mar;93(3):279-87. doi: 10.1007/s00109-015-1256-4. Epub 2015 Feb 5.

The processes that control the number and shape of the mitochondria (mitochondrial dynamics) and the removal of damaged mitochondria (mitophagy) have been the subject of intense research. Recent work indicates that these processes may contribute to the pathology associated with cardiac diseases. This review describes some of the key proteins that regulate these processes and their potential as therapeutic targets for cardiac diseases.

控制线粒体数量和形态的过程（线粒体动力学）以及清除受损线粒体的过程（线粒体自噬）一直是深入研究的主题。最近的研究表明，这些过程可能与心脏疾病相关的病理学有关。本综述描述了一些调节这些过程的关键蛋白质及其作为心脏疾病治疗靶点的潜力。