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成年囊性纤维化患者中由产KPC-3和耐黏菌素的肺炎克雷伯菌序列型258（ST258）引起慢性肺部感染的首例报告。

First report of chronic pulmonary infection by KPC-3-producing and colistin-resistant Klebsiella pneumoniae sequence type 258 (ST258) in an adult patient with cystic fibrosis.

作者信息

Delfino Emanuele, Giacobbe Daniele Roberto, Del Bono Valerio, Coppo Erika, Marchese Anna, Manno Graziana, Morelli Patrizia, Minicucci Laura, Viscoli Claudio

机构信息

Clinica Malattie Infettive, Università di Genova (DISSAL)-AOU IRCCS San Martino-IST, Genoa, Italy.

Clinica Malattie Infettive, Università di Genova (DISSAL)-AOU IRCCS San Martino-IST, Genoa, Italy

出版信息

J Clin Microbiol. 2015 Apr;53(4):1442-4. doi: 10.1128/JCM.03199-14. Epub 2015 Feb 4.

DOI:10.1128/JCM.03199-14
PMID:25653395
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4365242/
Abstract

The spread of Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae continues to increase, and the possible development of KPC-producing K. pneumoniae infections in cystic fibrosis (CF) patients is a matter of concern. Here, we describe the establishment of a chronic lung infection due to a colistin-resistant KPC-producing K. pneumoniae isolate in an Italian CF patient.

摘要

产肺炎克雷伯菌碳青霉烯酶（KPC）的肺炎克雷伯菌的传播持续增加，囊性纤维化（CF）患者中可能发生产KPC的肺炎克雷伯菌感染是一个令人担忧的问题。在此，我们描述了一名意大利CF患者因一株耐黏菌素的产KPC肺炎克雷伯菌分离株而导致慢性肺部感染的情况。

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本文引用的文献

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Int J Med Microbiol. 2014 May;304(3-4):415-21. doi: 10.1016/j.ijmm.2014.02.008. Epub 2014 Feb 19.
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Major variation in MICs of tigecycline in Gram-negative bacilli as a function of testing method.革兰氏阴性杆菌中替加环素最低抑菌浓度（MIC）随检测方法的变化很大。
J Clin Microbiol. 2014 May;52(5):1617-21. doi: 10.1128/JCM.00001-14. Epub 2014 Mar 5.
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Colonization of liver transplant recipients with KPC-producing Klebsiella pneumoniae is associated with high infection rates and excess mortality: a case-control analysis.产肺炎克雷伯菌碳青霉烯酶（KPC）的肺炎克雷伯菌定植于肝移植受者与高感染率和额外死亡率相关：一项病例对照分析。
Infection. 2014 Apr;42(2):309-16. doi: 10.1007/s15010-013-0547-3. Epub 2013 Nov 12.
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Clinical epidemiology of the global expansion of Klebsiella pneumoniae carbapenemases.全球扩展型碳青霉烯酶肺炎克雷伯菌的临床流行病学。
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