Byun Sung Hwan, Kwon Eun Byul, Kim Se Young
Department of Pediatrics, Bundang Jesaeng Hospital, Seongnam, Korea.
Korean J Pediatr. 2014 Dec;57(12):533-7. doi: 10.3345/kjp.2014.57.12.533. Epub 2014 Dec 31.
Obesity is related to systemic inflammatory processes causing cardiovascular complications. Intercellular adhesion molecule-1 (ICAM-1), CD40 ligand (CD40L), P-selectin are newly described mediators of inflammation and have a significant effect in atherosclerosis. Adiponectin has shown anti-inflammatory effects in adults. The aim of this study was to evaluate the relationship between adiponectin and inflammatory mediators in children and adolescents.
Fifty children or adolescents, twenty two with a body mass index (BMI) over 95th percentile, and twenty eight with a BMI below 75th percentile were included in the study. Serum soluble ICAM-1 (sICAM-1), P-selectin, CD40L, lipid profiles, aspartate aminotransferase, alanine aminotransferase, glucose and insulin were measured to evaluate associations with adiponectin. Comparison of these variables was performed between the obese and the nonobese group.
We found a adiponectin to be significant lower and sICAM-1 significant higher in the obese group compared to the nonobese group, but there were no significant differences in P-selectin and soluble CD40L. Adiponectin was negatively associated with ICAM-1 and P-selectin in the obese group.
Negative associations of adiponectin with ICAM-1 and P-selectin in obese children and adolescents suggest that serum adiponectin level may represent the inflammatory status.
肥胖与导致心血管并发症的全身炎症过程相关。细胞间黏附分子-1（ICAM-1）、CD40配体（CD40L）、P-选择素是新发现的炎症介质，在动脉粥样硬化中具有重要作用。脂联素在成年人中已显示出抗炎作用。本研究的目的是评估儿童和青少年中脂联素与炎症介质之间的关系。
本研究纳入了50名儿童或青少年，其中22名体重指数（BMI）超过第95百分位数，28名BMI低于第75百分位数。测量血清可溶性ICAM-1（sICAM-1）、P-选择素、CD40L、血脂谱、天冬氨酸转氨酶、丙氨酸转氨酶、葡萄糖和胰岛素，以评估与脂联素的相关性。在肥胖组和非肥胖组之间对这些变量进行比较。
我们发现，与非肥胖组相比，肥胖组的脂联素显著降低，sICAM-1显著升高，但P-选择素和可溶性CD40L没有显著差异。在肥胖组中，脂联素与ICAM-1和P-选择素呈负相关。
肥胖儿童和青少年中脂联素与ICAM-1和P-选择素的负相关表明血清脂联素水平可能代表炎症状态。
