Mao Yongtao, Xu Wei, Xie Zonggang, Dong Qirong
Department of Orthopeadic Surgery, The Second Affiliated Hospital of Soochow University , Suzhou, People's Republic of China .
Genet Test Mol Biomarkers. 2016 Feb;20(2):86-9. doi: 10.1089/gtmb.2015.0170. Epub 2015 Dec 1.
Irisin, a recently identified myokine, is implicated in protecting mice from obesity. This study was designed to examine the relation of irisin levels in serum and synovial fluid (SF) with the radiographic severity of osteoarthritis (OA).
Our study included 215 patients with knee OA. Irisin levels in serum and SF were evaluated using an enzyme-linked immunosorbent assay. The progression of OA was assessed using Kellgren-Lawrence grading system.
Knee OA patients had lower serum irisin concentrations and increased serum C-reactive protein (CRP) levels compared with healthy controls. There were markedly decreased irisin levels in both the serum and the SF, as well as increased serum CRP levels of knee OA patients with Kellgren and Lawrence (KL) grade 4 compared with patients classified as KL grade 2 and 3. Furthermore, patients with KL grade 3 showed markedly reduced serum and SF levels of irisin, as well as increased serum CRP levels compared with patients classified as KL grade 2. Irisin levels in serum and SF of knee OA patients were negatively correlated with disease severity evaluated by KL grading criteria.
Irisin levels in the serum and SF of knee OA patients were negatively correlated with disease severity evaluated by the radiographic KL grading criteria.
鸢尾素是一种最近发现的肌动蛋白，与保护小鼠免受肥胖影响有关。本研究旨在探讨血清和滑液（SF）中鸢尾素水平与骨关节炎（OA）影像学严重程度之间的关系。
我们的研究纳入了215例膝骨关节炎患者。采用酶联免疫吸附测定法评估血清和滑液中的鸢尾素水平。使用凯尔格伦-劳伦斯分级系统评估骨关节炎的进展。
与健康对照组相比，膝骨关节炎患者的血清鸢尾素浓度较低，血清C反应蛋白（CRP）水平升高。与凯尔格伦和劳伦斯（KL）2级和3级患者相比，KL 4级膝骨关节炎患者的血清和滑液中鸢尾素水平均显著降低，血清CRP水平升高。此外，与KL 2级患者相比，KL 3级患者的血清和滑液鸢尾素水平显著降低，血清CRP水平升高。膝骨关节炎患者血清和滑液中的鸢尾素水平与通过KL分级标准评估的疾病严重程度呈负相关。
膝骨关节炎患者血清和滑液中的鸢尾素水平与通过影像学KL分级标准评估的疾病严重程度呈负相关。
