Mariam Sarah, Kshirsagar Rajesh, Hasan Shamimul, Khadtare Yogesh, Rajpurohit Komal S, Rai Himanshi, Newaskar Devashri, Deo Priya
Periodontology, Bharati Vidyapeeth (Deemed to be University), Pune, IND.
Oral and Maxillofacial Surgery, Bharati Vidyapeeth (Deemed to be University), Pune, IND.
Cureus. 2024 Aug 19;16(8):e67173. doi: 10.7759/cureus.67173. eCollection 2024 Aug.
Dental implants constitute an important treatment modality for rehabilitating edentulous and partially edentulous arches. With more implant systems in the market, understanding the mechanical aspects of implants is crucial in understanding this indispensable therapy. However, microflora-related factors i.e. biological factors are also crucial. Despite the tremendous success rate of dental implants, it is not averse to failure. Both mechanical and microbial aspects in seclusion or together predispose to implant failure. Newer technological advances have paved the way for advanced techniques to identify the not-so-common flora causing implant failure. This review focuses on detailed mechanical and biological aspects and the sealing agent used to seal the implant-abutment interface. It also focuses on advanced molecular techniques like metagenomics and transcriptomics. A thorough literature search was performed with selected articles from electronic databases. A combination of in-vivo and in-vitro studies were considered to provide comprehensive information on the subject. Both the biomechanical aspects like micro gap, and microleakage, as well as microbial movements play confluent roles in implant failure. The focus should be on the different aspects through which microflora can penetrate the inner parts of the implant. Also, newer culture-independent techniques of detecting previously undetected oral flora should be included in future studies.
牙种植体是修复无牙和部分无牙牙弓的一种重要治疗方式。随着市场上出现更多的种植系统，了解种植体的力学方面对于理解这种不可或缺的治疗方法至关重要。然而，微生物相关因素，即生物学因素也很关键。尽管牙种植体的成功率很高，但它并非不会失败。单独或共同存在的力学和微生物方面的因素都会导致种植体失败。新的技术进步为识别导致种植体失败的不太常见菌群的先进技术铺平了道路。本综述重点关注详细的力学和生物学方面以及用于封闭种植体-基台界面的封闭剂。它还关注宏基因组学和转录组学等先进的分子技术。通过对电子数据库中选定的文章进行了全面的文献检索。考虑结合体内和体外研究以提供关于该主题的全面信息。微间隙和微渗漏等生物力学方面以及微生物活动在种植体失败中都起着共同作用。重点应放在微生物可以通过哪些不同方面渗透到种植体内部。此外，未来的研究应纳入检测以前未检测到的口腔菌群的更新的非培养技术。
