Castro Carlos E, Su Hai-Jun, Marras Alexander E, Zhou Lifeng, Johnson Joshua
Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, OH 43210, USA.
Nanoscale. 2015 Apr 14;7(14):5913-21. doi: 10.1039/c4nr07153k.
Structural DNA nanotechnology is a rapidly emerging field that has demonstrated great potential for applications such as single molecule sensing, drug delivery, and templating molecular components. As the applications of DNA nanotechnology expand, a consideration of their mechanical behavior is becoming essential to understand how these structures will respond to physical interactions. This review considers three major avenues of recent progress in this area: (1) measuring and designing mechanical properties of DNA nanostructures, (2) designing complex nanostructures based on imposed mechanical stresses, and (3) designing and controlling structurally dynamic nanostructures. This work has laid the foundation for mechanically active nanomachines that can generate, transmit, and respond to physical cues in molecular systems.
结构DNA纳米技术是一个迅速兴起的领域，已在单分子传感、药物递送和分子组件模板等应用中展现出巨大潜力。随着DNA纳米技术应用范围的扩大，考虑其力学行为对于理解这些结构如何响应物理相互作用变得至关重要。本综述探讨了该领域近期取得进展的三个主要方向：（1）测量和设计DNA纳米结构的力学性能；（2）基于施加的机械应力设计复杂的纳米结构；（3）设计和控制结构动态的纳米结构。这项工作为可在分子系统中产生、传递和响应物理信号的机械活性纳米机器奠定了基础。
