Department of Public Health Dentistry, Thai Moogambigai Dental College and Hospital, Dr. M.G.R. Educational and Research Institute, Chennai 600107, Tamil Nadu, India.
Department of Clinical Sciences, Centre of Medical and Bio-Allied Health Sciences and Research, Ajman University, Ajman P.O. Box 346, United Arab Emirates.
Molecules. 2023 Jul 14;28(14):5395. doi: 10.3390/molecules28145395.
Throughout the world, oral cancer is a common and aggressive malignancy with a high risk of morbidity, mortality, and recurrence. The importance of early detection in cancer prevention and disease treatment cannot be overstated. Conventional therapeutic strategies have minor difficulties but considerable side effects and unfavourable consequences in clinical applications. Hence, there is a requirement for effective ways for early detection and treatment of oral cancer. At present, numerous forms of nanoparticles have piqued researchers' interest as a potentially useful tool for diagnostic probes and medicinal devices. Because of their inherent physicochemical properties and customizable surface modification, they are able to circumvent some of restrictions and accomplish the intended diagnostic and therapeutic impact. Nanotechnology is a unique field that has revolutionised the industry and is paving the way for new treatments for oral cancer. It can help with a better diagnosis with less harmful substances and is setting current guidelines for treatment. The use of nanotechnology in cancer diagnosis, therapy, and care improves clinical practise dramatically. The different types of nanoparticles that have been developed for the diagnosis and therapy of oral cancers will be covered in this study. The difficulties and potential uses of nanoparticles in the treatment and diagnosis of oral cancer are then highlighted. In order to emphasise existing difficulties and potential remedies for oral cancer, a prospective view of the future is also provided.
在全球范围内，口腔癌是一种常见且侵袭性强的恶性肿瘤，具有高发病率、死亡率和复发率。早期发现对于癌症预防和疾病治疗的重要性怎么强调都不为过。传统的治疗策略在临床应用中存在一些小的困难，但副作用较大，结果不理想。因此，需要有效的方法来早期检测和治疗口腔癌。目前，由于其固有物理化学性质和可定制的表面修饰，许多类型的纳米颗粒已引起研究人员的兴趣，被认为是诊断探针和药物输送装置的潜在有用工具。纳米技术是一个独特的领域，它彻底改变了行业，为口腔癌的新治疗方法铺平了道路。它可以帮助进行更准确的诊断，使用更少的有害物质，并为治疗制定当前的指导方针。纳米技术在癌症诊断、治疗和护理中的应用极大地改善了临床实践。本研究将介绍为诊断和治疗口腔癌而开发的不同类型的纳米颗粒。然后强调了纳米颗粒在口腔癌治疗和诊断中的困难和潜在用途。为了强调口腔癌的现有困难和潜在的解决方案，还提供了对未来的前瞻性展望。
