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细胞质肌动蛋白是一种细胞外昆虫免疫因子，在免疫刺激时分泌，介导吞噬作用并直接杀死细菌，是疟原虫的拮抗剂。

Cytoplasmic actin is an extracellular insect immune factor which is secreted upon immune challenge and mediates phagocytosis and direct killing of bacteria, and is a Plasmodium Antagonist.

作者信息

Sandiford Simone L, Dong Yuemei, Pike Andrew, Blumberg Benjamin J, Bahia Ana C, Dimopoulos George

机构信息

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, United States of America.

出版信息

PLoS Pathog. 2015 Feb 6;11(2):e1004631. doi: 10.1371/journal.ppat.1004631. eCollection 2015 Feb.

DOI:10.1371/journal.ppat.1004631
PMID:25658622
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4450071/
Abstract

Actin is a highly versatile, abundant, and conserved protein, with functions in a variety of intracellular processes. Here, we describe a novel role for insect cytoplasmic actin as an extracellular pathogen recognition factor that mediates antibacterial defense. Insect actins are secreted from cells upon immune challenge through an exosome-independent pathway. Anopheles gambiae actin interacts with the extracellular MD2-like immune factor AgMDL1, and binds to the surfaces of bacteria, mediating their phagocytosis and direct killing. Globular and filamentous actins display distinct functions as extracellular immune factors, and mosquito actin is a Plasmodium infection antagonist.

摘要

肌动蛋白是一种高度通用、丰富且保守的蛋白质，在多种细胞内过程中发挥作用。在此，我们描述了昆虫细胞质肌动蛋白作为一种细胞外病原体识别因子介导抗菌防御的新作用。昆虫肌动蛋白在免疫挑战时通过不依赖外泌体的途径从细胞中分泌出来。冈比亚按蚊肌动蛋白与细胞外类MD2免疫因子AgMDL1相互作用，并结合到细菌表面，介导其吞噬和直接杀伤。球状和丝状肌动蛋白作为细胞外免疫因子发挥不同功能，且蚊子肌动蛋白是疟原虫感染的拮抗剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df9d/4450071/7af3990f39de/ppat.1004631.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df9d/4450071/0e27dab8ce98/ppat.1004631.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df9d/4450071/d842cdfc1599/ppat.1004631.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df9d/4450071/2a603056ebdd/ppat.1004631.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df9d/4450071/aa2e53c78988/ppat.1004631.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df9d/4450071/7a5c460e7cf4/ppat.1004631.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df9d/4450071/7af3990f39de/ppat.1004631.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df9d/4450071/0e27dab8ce98/ppat.1004631.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df9d/4450071/d842cdfc1599/ppat.1004631.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df9d/4450071/2a603056ebdd/ppat.1004631.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df9d/4450071/aa2e53c78988/ppat.1004631.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df9d/4450071/7a5c460e7cf4/ppat.1004631.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df9d/4450071/7af3990f39de/ppat.1004631.g006.jpg

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