Maesawa Satoshi, Bagarinao Epifanio, Fujii Masazumi, Futamura Miyako, Motomura Kazuya, Watanabe Hirohisa, Mori Daisuke, Sobue Gen, Wakabayashi Toshihiko
Brain and Mind Research Center, Nagoya University, Nagoya City, Aichi, Japan; Department of Neurosurgery, Nagoya University School of Medicine, Nagoya City, Aichi, Japan.
Brain and Mind Research Center, Nagoya University, Nagoya City, Aichi, Japan.
PLoS One. 2015 Feb 6;10(2):e0118072. doi: 10.1371/journal.pone.0118072. eCollection 2015.
In this study, we investigated changes in resting state networks (RSNs) in patients with gliomas located in the left hemisphere and its relation to cognitive function. We hypothesized that long distance connection, especially between hemispheres, would be affected by the presence of the tumor. We further hypothesized that these changes would correlate with, or reflect cognitive changes observed in patients with gliomas. Resting state functional MRI datasets from 12 patients and 12 healthy controls were used in the analysis. The tumor's effect on three well-known RSNs including the default mode network (DMN), executive control network (ECN), and salience network (SN) identified using independent component analysis were investigated using dual regression analysis. Scores of neuropsychometric testing (WAIS-III and WMS-R) were also compared. Compared to the healthy control group, the patient group showed significant decrease in functional connectivity in the right angular gyrus/inferior parietal lobe of the ventral DMN and in the dorsolateral prefrontal cortex of the left ECN, whereas a significant increase in connectivity in the right ECN was observed in the right parietal lobe. Changes in connectivity in the right ECN correlated with spatial memory, while that on the left ECN correlated with attention. Connectivity changes in the ventral DMN correlated with attention, working memory, full IQ, and verbal IQ measures. Although the tumors were localized in the left side of the brain, changes in connectivity were observed in the contralateral side. Moreover, these changes correlated with some aspects of cognitive function indicating that patients with gliomas may undergo cognitive changes even in the absence of or before the onset of major symptoms. Evaluation of resting state networks could be helpful in advancing our hodological understanding of brain function in glioma cases.
在本研究中，我们调查了位于左半球的胶质瘤患者静息态网络（RSN）的变化及其与认知功能的关系。我们假设长距离连接，尤其是半球之间的连接，会受到肿瘤存在的影响。我们进一步假设这些变化将与胶质瘤患者中观察到的认知变化相关或反映这些变化。分析中使用了12名患者和12名健康对照的静息态功能磁共振成像数据集。使用双回归分析研究了肿瘤对通过独立成分分析确定的三个著名RSN的影响，包括默认模式网络（DMN）、执行控制网络（ECN）和突显网络（SN）。还比较了神经心理测试（韦氏成人智力量表第三版和韦氏记忆量表修订版）的分数。与健康对照组相比，患者组在腹侧DMN的右角回/下顶叶以及左ECN的背外侧前额叶皮质中的功能连接显著降低，而在右顶叶的右ECN中观察到连接显著增加。右ECN中的连接变化与空间记忆相关，而左ECN中的连接变化与注意力相关。腹侧DMN中的连接变化与注意力、工作记忆、全智商和言语智商测量相关。尽管肿瘤位于大脑左侧，但在对侧观察到了连接变化。此外，这些变化与认知功能的某些方面相关，表明即使在没有主要症状或主要症状出现之前，胶质瘤患者也可能发生认知变化。评估静息态网络可能有助于推进我们对胶质瘤病例脑功能的传导通路理解。
