来自拟无枝酸菌属菌株LZ149的具有抗分枝杆菌活性的铁载体螯合剂。
Siderochelins with anti-mycobacterial activity from Amycolatopsis sp. LZ149.
作者信息
Lu Chun-Hua, Ye Fang-Wen, Shen Yue-Mao
机构信息
Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China.
School of Life Sciences, Xiamen University, Xiamen 361005, china.
出版信息
Chin J Nat Med. 2015 Jan;13(1):69-72. doi: 10.1016/S1875-5364(15)60009-7.
Three new compounds, namely siderochelins D (2), E (3), and F (4), together with one known siderochelin A (1), were isolated from Amycolatopsis sp. LZ149 and elucidated by spectroscopic analyses including1D- and 2D-NMR and X-ray single crystal diffraction. Compounds 1-3 showed antibacterial activity against Mycobacterium smegmatis.
从 Amycolatopsis sp. LZ149 中分离出三种新化合物，即铁载体螯合素 D（2）、E（3）和 F（4），以及一种已知的铁载体螯合素 A（1），并通过包括一维和二维核磁共振以及 X 射线单晶衍射在内的光谱分析对其进行了鉴定。化合物 1-3 对耻垢分枝杆菌显示出抗菌活性。
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