慢性阻塞性肺疾病患者血清血管内皮生长因子水平
Serum levels of vascular endothelial growth factor in chronic obstructive pulmonary disease.
作者信息
Farid Hosseini Reza, Jabbari Azad Farahzad, Yousefzadeh Hadis, Rafatpanah Houshang, Hafizi Saeed, Tehrani Homan, Khani Masoud
机构信息
1. MD, Professor of Allergy and Clinical Immunology, Allergy Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
2. MD, Associate Professor of Allergy and clinical immunology, Allergy Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
Med J Islam Repub Iran. 2014 Aug 2;28:85. eCollection 2014.
BACKGROUND
Chronic obstructive pulmonary disease (COPD) is a third leading cause of death.
METHODS
In this case control study, we prepared 5 cc bloods from the antecubital vein of 100 COPD patients and 40 healthy individuals as control group. Vascular endothelial growth factor (VEGF) expression protein level was measured by ELISA in both groups.
RESULTS
We found that concentration of VEGF in blood serum of patients with COPD (189.9±16pg/ml) was significantly higher than the control group (16.4±3.48pg/ml) (p<0.001). While VEGF serum level in emphysematous patients wasn't significantly different with control group (p=0.07). Furthermore VEGF serum level in COPD patients was proportionally increased with severity of disease (p<0.001). Besides all COPD patients, regardless of their smoking status, were experienced significantly higher levels of VEGF than healthy ones (p=0.001; z=4.3).
CONCLUSION
Our results suggest VEGF serum concentration as the sensitive index for severity and activity of COPD and its prognosis.
背景
慢性阻塞性肺疾病（COPD）是第三大致死原因。
方法
在本病例对照研究中，我们从100例COPD患者的肘前静脉采集5毫升血液，并采集40名健康个体的血液作为对照组。两组均采用酶联免疫吸附测定法（ELISA）检测血管内皮生长因子（VEGF）表达蛋白水平。
结果
我们发现，COPD患者血清中VEGF浓度（189.9±16皮克/毫升）显著高于对照组（16.4±3.48皮克/毫升）（p<0.001）。而肺气肿患者的VEGF血清水平与对照组无显著差异（p=0.07）。此外，COPD患者的VEGF血清水平随疾病严重程度呈比例增加（p<0.001）。此外，所有COPD患者，无论其吸烟状况如何，其VEGF水平均显著高于健康人（p=0.001；z=4.3）。
结论
我们的结果表明，VEGF血清浓度是COPD严重程度、活动度及其预后的敏感指标。
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