2型糖尿病患者血清胎球蛋白-A水平与载脂蛋白A1、载脂蛋白B100、身体成分及胰岛素抵抗的关系
Relationship between serum levels of fetuin-A with apo-A1, apo-B100, body composition and insulin resistance in patients with type 2 diabetes.
作者信息
Shidfar Farzad, Zarrati Mitra, Khamseh Mohamad Ebrahim, Haghighat Neda, Rostami Ali, Zolfaghari Hamid
机构信息
1. PhD. Professor of Nutrition, Institute of Endocrinology and Metabolism Research and Training Center, Iran University of Medical Sciences, Tehran, Iran.
2. PhD, Institute of Endocrinology and Metabolism Research and Training Center, Iran University of Medical Sciences, Tehran, Iran.
出版信息
Med J Islam Repub Iran. 2014 Sep 20;28:100. eCollection 2014.
BACKGROUND
Some results exist on fetuin-A as marker for vascular disease in type 2diabetes. We examined the relationship between serum fetuin-A with some factors, in patients with type 2 diabetes mellitus (T2DM).
METHODS
From October 2012 to June 2013, a total of 131 T2DM patients were recruited and evaluated for various parameters including HOMA-IR, Apo-A1, Apo-B100, body fat percentage and waist circumference. Serum fetuin-A levels were measured by enzyme-linkedimmunosorbent assay (ELISA), and Serum glucose with a Cobas MIRA analyzer by enzymatic method. Apo-B100 and apo-A1 were measured by immunoturbidimetry with a Cobas MIRA analyzer. HOMA-IR was calculated by the following formula: [fasting insulin (uIU/mL) × fasting blood glucose (mmol/L)]/22.5.
RESULTS
The mean levels of HOMA-IR were significantly increased progressively across fetuin-A tertiles (p for trend=0.04) in women but not men. Fetuin-A had just a significant positive correlation with Apo- A1(r=0.22, p=0.02).
CONCLUSION
This present study showed that levels of serum fetuin-A are significantly associated with insulin resistance in women with T2DM.
背景
关于胎球蛋白-A作为2型糖尿病血管疾病标志物已有一些研究结果。我们研究了2型糖尿病（T2DM）患者血清胎球蛋白-A与一些因素之间的关系。
方法
2012年10月至2013年6月，共招募了131例T2DM患者，并对其进行了包括HOMA-IR、载脂蛋白A1、载脂蛋白B100、体脂百分比和腰围等各项参数的评估。采用酶联免疫吸附测定（ELISA）法检测血清胎球蛋白-A水平，用Cobas MIRA分析仪通过酶法检测血清葡萄糖。用Cobas MIRA分析仪通过免疫比浊法检测载脂蛋白B100和载脂蛋白A1。HOMA-IR通过以下公式计算：[空腹胰岛素（uIU/mL）×空腹血糖（mmol/L）]/22.5。
结果
在女性中，HOMA-IR的平均水平在胎球蛋白-A三分位数中呈显著逐步升高趋势（趋势p值=0.04），而在男性中并非如此。胎球蛋白-A仅与载脂蛋白A呈显著正相关（r=0.22，p=0.02）。
结论
本研究表明，血清胎球蛋白-A水平与T2DM女性患者的胰岛素抵抗显著相关。
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