Gao Jin-Liao, Xue Qiao, Wang Shi-Wen, Gao Li-Fei, Lan Yun-Feng, Fang Zhou, Fu Yi-Cheng, Liu Yan, Li Yang, Fan Li
First Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, 100853, China.
Department of Cardiology, Chinese PLA General Hospital, Beijing, 100853, China.
J Huazhong Univ Sci Technolog Med Sci. 2015 Feb;35(1):28-34. doi: 10.1007/s11596-015-1384-7. Epub 2015 Feb 12.
This study was aimed to investigate the effect of stress induced by high-intensity exercises on the cardiovascular system. In the epidemiological investigation, 200 subjects (test group) engaged in special high-intensity exercises, and 97 who lived and worked in the same environment and conditions as those in the test group, but did not participate in the exercises served as controls. In the second part of the study, 50 mice were randomly divided into control group, exhaustive swimming group, white noise group, exhaustive swimming plus white noise group, and pioglitazone intervention group. The results showed that the plasma concentrations of the myocardial injury markers heart fatty acid-binding protein (H-FABP), C-reactive protein (CRP), β-endorphin (β-EP) and levels of psychological stress were significantly increased in test group as compared with control group; special high-intensity exercises resulted in a significant elevation of the incidence of cardiac arrhythmias. Animal experiments showed that the plasma levels of corticosterone (CORT) and troponin I (TnI) were raised while the level of SOD was reduced in exhaustive swimming group, white noise group, and exhaustive swimming plus white noise group. The expression levels of PPARγ mRNA and protein were decreased in myocardial tissues in these groups as well. HE staining showed no remarkable change in myocardial tissues in all the groups. Treatment with pioglitazone significantly decreased the plasma levels of TnI and CORT, while increased the level of SOD and the expression levels of PPARγ mRNA and protein. It was concluded that the high-intensity exercises may induce a heavy physical and psychological stress and predispose the subjects to accumulated fatigue and sleep deprivation; high-intensity exercises also increases the incidence of arrhythmias and myocardial injury. PPARγ may be involved in the physical and psychological changes induced by high-intensity exercises.
本研究旨在探讨高强度运动所诱发的应激对心血管系统的影响。在流行病学调查中，200名受试者（试验组）进行特殊的高强度运动，97名在与试验组相同环境和条件下生活工作但未参与运动的人员作为对照组。在研究的第二部分，50只小鼠被随机分为对照组、力竭游泳组、白噪声组、力竭游泳加白噪声组以及吡格列酮干预组。结果显示，与对照组相比，试验组中心肌损伤标志物心脏脂肪酸结合蛋白（H-FABP）、C反应蛋白（CRP）、β-内啡肽（β-EP）的血浆浓度以及心理应激水平显著升高；特殊高强度运动导致心律失常发生率显著升高。动物实验表明，力竭游泳组、白噪声组以及力竭游泳加白噪声组中皮质酮（CORT）和肌钙蛋白I（TnI）的血浆水平升高，而超氧化物歧化酶（SOD）水平降低。这些组心肌组织中PPARγ mRNA和蛋白的表达水平也降低。HE染色显示所有组心肌组织均无明显变化。吡格列酮治疗显著降低了TnI和CORT的血浆水平，同时提高了SOD水平以及PPARγ mRNA和蛋白的表达水平。研究得出结论，高强度运动可能诱发严重的身心应激，使受试者易出现累积性疲劳和睡眠剥夺；高强度运动还会增加心律失常和心肌损伤的发生率。PPARγ可能参与了高强度运动所诱发的身心变化。
