Gomes T A, Vieira M A, Wachsmuth I K, Blake P A, Trabulsi L R
Department of Microbiology, Immunology, and Parasitology, Escola Paulista de Medicina, São Paulo, Brazil.
J Infect Dis. 1989 Jul;160(1):131-5. doi: 10.1093/infdis/160.1.131.
To examine interrelationships of classic enteropathogenic Escherichia coli (EPEC) serotypes, EPEC adherence factor (EAF) genes, and diarrheal disease, E. coli were studied from stools of 500 infants less than 1 y of age with acute diarrhea and 500 age-matched controls. EAF-containing (EAF+) E. coli of three common classic EPEC serotypes (O111:H-, odds ratio [OR] 36.0; O111:H2, OR 55.0; O119:H6, OR 3.7) were individually strongly associated with diarrhea, as were EAF+ strains of less common classic serotypes combined (OR 5.3). Among EPEC serogroups, neither EAF+ strains of nonclassic serotypes (OR 1.8) nor EAF-strains of classic (OR 2.2) or nonclassic (OR 1.4) serotypes were significantly associated with diarrhea. At least one EAF+ non-EPEC serogroup serotype (O88:H25) may represent an unrecognized EPEC serotype. Serotype-specific variation in the association of EAF+ E. coli with diarrhea suggests that other factors are also important in determining virulence; thus, both EAF detection and E. coli serotyping are desirable in studying the etiology of diarrheal disease.
为研究经典肠致病性大肠杆菌（EPEC）血清型、EPEC黏附因子（EAF）基因与腹泻病之间的相互关系，对500名1岁以下患急性腹泻的婴儿粪便中的大肠杆菌以及500名年龄匹配的对照者粪便中的大肠杆菌进行了研究。三种常见经典EPEC血清型（O111:H-，优势比[OR]36.0；O111:H2，OR 55.0；O119:H6，OR 3.7）的含EAF（EAF+）大肠杆菌个体与腹泻密切相关，较少见经典血清型的EAF+菌株合并在一起时也是如此（OR 5.3）。在EPEC血清群中，非经典血清型的EAF+菌株（OR 1.8）以及经典（OR 2.2）或非经典（OR 1.4）血清型的EAF-菌株与腹泻均无显著关联。至少有一种EAF+非EPEC血清群血清型（O88:H25）可能代表一种未被识别的EPEC血清型。EAF+大肠杆菌与腹泻关联中的血清型特异性差异表明，其他因素在决定毒力方面也很重要；因此，在研究腹泻病的病因时，EAF检测和大肠杆菌血清分型均很有必要。
