Wen Zhi-Qiang, Du Jing-Yu, Ling Zhi-Heng, Xu Hai-Dong, Lin Xiang-Jin
Department of Orthopaedics, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China.
Department of Spine Surgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, People's Republic of China.
Ther Clin Risk Manag. 2015 Jan 29;11:161-70. doi: 10.2147/TCRM.S72699. eCollection 2015.
To date, the decision to treat multilevel cervical spondylotic myelopathy (CSM) with anterior cervical discectomy and fusion (ACDF) or anterior cervical corpectomy and fusion (ACCF) remains controversial. Therefore, we conducted a meta-analysis to quantitatively determine the efficacy of ACDF and ACCF in the treatment of multilevel CSM.
We searched several databases for related research articles published in English or Chinese. We extracted and assessed the data independently. We determined the pooled data, data heterogeneity, and overall effect, respectively.
We identified 15 eligible studies with 1,368 patients. We found that blood loss and numbers of complications during surgery in ACDF were significantly less that in ACCF; however, other clinical outcomes, such as operation time, bone fusion failure, post Japanese Orthopedic Association scores, recovery rates, and visual analog scale scores between ACDF and ACCF with multilevel CSM were not significantly different.
Our results strongly suggest that surgical treatments of multilevel CSM are similar in terms of most clinical outcomes using ACDF or ACCF.
迄今为止,对于多节段脊髓型颈椎病(CSM)采用颈椎前路椎间盘切除融合术(ACDF)还是颈椎前路椎体次全切除融合术(ACCF)进行治疗仍存在争议。因此,我们进行了一项荟萃分析,以定量确定ACDF和ACCF治疗多节段CSM的疗效。
我们在多个数据库中检索以英文或中文发表的相关研究文章。我们独立提取并评估数据。我们分别确定合并数据、数据异质性和总体效应。
我们纳入了15项符合条件的研究,共1368例患者。我们发现,ACDF手术中的失血量和并发症数量显著少于ACCF;然而,ACDF和ACCF治疗多节段CSM的其他临床结果,如手术时间、骨融合失败、日本骨科协会术后评分、恢复率和视觉模拟量表评分,差异均无统计学意义。
我们的结果强烈表明,使用ACDF或ACCF治疗多节段CSM的大多数临床结果相似。