Gläser Sven, Krüger Stefan, Merkel Martin, Bramlage Peter, Herth Felix J F
Department of Internal Medicine B - Cardiology, Intensive Care, Pulmonary Medicine and Infectious Diseases and Scientific Division of Pneumological Research and Pneumological Epidemiology, University of Greifswald, Greifswald, Germany.
Respiration. 2015;89(3):253-64. doi: 10.1159/000369863. Epub 2015 Feb 13.
The objective of this systematic review was to discuss our current understanding of the complex relationship between chronic obstructive pulmonary disease (COPD) and type-2 diabetes mellitus (T2DM). We performed a systematic search of the literature related to both COPD and diabetes using PubMed. Relevant data connecting both diseases were compiled and discussed. Recent evidence suggests that diabetes can worsen the progression and prognosis of COPD; this may result from the direct effects of hyperglycemia on lung physiology, inflammation or susceptibility to bacterial infection. Conversely, it has also been suggested that COPD increases the risk of developing T2DM as a consequence of inflammatory processes and/or therapeutic side effects related to the use of high-dose corticosteroids. In conclusion, although there is evidence to support a connection between COPD and diabetes, additional research is needed to better understand these relationships and their possible implications.
本系统评价的目的是探讨我们目前对慢性阻塞性肺疾病（COPD）与2型糖尿病（T2DM）之间复杂关系的理解。我们使用PubMed对与COPD和糖尿病相关的文献进行了系统检索。收集并讨论了连接这两种疾病的相关数据。最近的证据表明，糖尿病会使COPD的进展和预后恶化；这可能是由于高血糖对肺生理、炎症或细菌感染易感性的直接影响。相反，也有人提出，由于炎症过程和/或与使用高剂量皮质类固醇相关的治疗副作用，COPD会增加患T2DM的风险。总之，尽管有证据支持COPD与糖尿病之间存在联系，但仍需要进一步研究以更好地理解这些关系及其可能的影响。
