居住在高速公路附近与墨西哥裔美国人较低的骨矿物质密度有关。
Living near a freeway is associated with lower bone mineral density among Mexican Americans.
作者信息
Chen Z, Salam M T, Karim R, Toledo-Corral C M, Watanabe R M, Xiang A H, Buchanan T A, Habre R, Bastain T M, Lurmann F, Taher M, Wilson J P, Trigo E, Gilliland F D
机构信息
Southern California Environmental Health Sciences Center, Division of Environmental Health, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, 2001 N. Soto Street, Los Angeles, CA, 90032, USA.
Division of Biostatistics, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
出版信息
Osteoporos Int. 2015 Jun;26(6):1713-21. doi: 10.1007/s00198-015-3051-z. Epub 2015 Feb 13.
UNLABELLED
We hypothesized that chronic exposures to traffic combustion products may lower bone mineral density (BMD). We found that proximity to freeways was associated with reduced BMD. Our findings suggest that traffic-related pollution may contribute to the occurrence of osteopenia and osteoporosis.
INTRODUCTION
Adults residing in rural areas have been linked with higher BMD. We aimed to determine if this difference is due in part to air pollution by examining the relationships between traffic metrics and ambient air pollution with total body and pelvic BMD.
METHODS
Mexican American adults (n = 1,175; mean 34 years; 72 % female) who had participated in the BetaGene study of air pollution, obesity, and insulin resistance were included in this analysis. Total body and pelvic BMD were estimated using dual-energy X-ray absorptiometry. Traffic and ambient air pollutant exposures were estimated at residences using location and ambient monitoring data. Variance component models were used to analyze the associations between residential distance to the nearest freeway and ambient air pollutants with BMD.
RESULTS
Residential proximity to a freeway was associated with lower total body BMD (p-trend = 0.01) and pelvic BMD (p-trend = 0.03) after adjustment for age, sex, weight, and height. The adjusted mean total body and pelvic BMD in participants living within 500 m of a freeway were 0.02 and 0.03 g/cm(2) lower than participants living greater than 1,500 m from a freeway. These associations did not differ significantly by age, sex, or obesity status. Results were similar after further adjustment for body fat and weekly physical activity minutes. Ambient air pollutants (NO2, O3, and PM2.5) were not significantly associated with BMD.
CONCLUSIONS
Traffic-related exposures in overweight and obese Mexican Americans may adversely affect BMD. Our findings indicate that long-term exposures to traffic may contribute to the occurrence of osteoporosis and its consequences.
未标注
我们假设长期暴露于交通燃烧产物可能会降低骨密度（BMD）。我们发现靠近高速公路与骨密度降低有关。我们的研究结果表明，与交通相关的污染可能导致骨质减少和骨质疏松的发生。
引言
居住在农村地区的成年人骨密度较高。我们旨在通过研究交通指标和环境空气污染与全身及骨盆骨密度之间的关系，来确定这种差异是否部分归因于空气污染。
方法
纳入参加空气污染、肥胖和胰岛素抵抗的BetaGene研究的墨西哥裔美国成年人（n = 1175；平均34岁；72%为女性）。使用双能X线吸收法估算全身和骨盆骨密度。利用位置和环境监测数据估算住所的交通和环境空气污染物暴露情况。采用方差成分模型分析住所到最近高速公路的距离和环境空气污染物与骨密度之间的关联。
结果
在调整年龄、性别、体重和身高后，住所靠近高速公路与较低的全身骨密度（p趋势 = 0.01）和骨盆骨密度（p趋势 = 0.03）相关。居住在距离高速公路500米以内的参与者，其调整后的平均全身和骨盆骨密度分别比居住在距离高速公路1500米以上的参与者低0.02和0.03 g/cm² 。这些关联在年龄、性别或肥胖状态方面无显著差异。在进一步调整体脂和每周体育活动分钟数后，结果相似。环境空气污染物（二氧化氮、臭氧和细颗粒物2.5）与骨密度无显著关联。
结论
超重和肥胖的墨西哥裔美国人中与交通相关的暴露可能会对骨密度产生不利影响。我们的研究结果表明，长期暴露于交通环境可能导致骨质疏松及其后果的发生。
Zotero 插件