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Filaggrin gene mutations are not associated with food and aeroallergen sensitization without concomitant atopic dermatitis in adults.

作者信息

Thyssen Jacob P, Tang Line, Husemoen Lise Lotte N, Stender Steen, Szecsi Pal B, Menné Torkil, Johansen Jeanne D, Linneberg Allan

机构信息

National Allergy Research Centre, Department of Dermato-Allergology, Copenhagen University Hospital Gentofte, Gentofte, Denmark.

Research Centre for Prevention and Health, Capital Region of Denmark, Copenhagen, Denmark.

出版信息

J Allergy Clin Immunol. 2015 May;135(5):1375-8.e1. doi: 10.1016/j.jaci.2015.01.001. Epub 2015 Feb 10.

DOI:10.1016/j.jaci.2015.01.001
PMID:25678087
Abstract
摘要

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Filaggrin gene mutations are not associated with food and aeroallergen sensitization without concomitant atopic dermatitis in adults.在成人中,丝聚合蛋白基因突变与无特应性皮炎伴发的食物及气源性变应原致敏无关。
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Filaggrin loss-of-function mutations do not predict food allergy over and above the risk of food sensitization among infants.在婴儿中,除食物致敏风险外,丝聚合蛋白功能丧失突变并不能预测食物过敏。
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