Glise H
Department of Surgery, NAL, Trollhättan, Sweden.
Scand J Gastroenterol Suppl. 1989;156:57-64. doi: 10.3109/00365528909091039.
Gastroesophageal reflux is a daily occurrence in the general population. Reflux esophagitis is less common but still a considerable clinical problem. The results of medical therapy are generally clearly inferior to those seen in peptic ulcer disease. After healing relapse is rapid and maintenance has not been proved superior to placebo. The promising results with omeprazole (inducing pronounced acid inhibition) and surgery (strengthening anti-reflux mechanisms) indicate that a more aggressive approach may be needed in future treatment. Additional studies also using combinations of drugs both in the healing stage and during maintenance is needed. These should be compared to the long-term results of surgery.
胃食管反流在普通人群中每天都会发生。反流性食管炎不太常见，但仍是一个相当严重的临床问题。药物治疗的效果通常明显逊于消化性溃疡疾病。愈合后复发迅速，且维持治疗并未被证明优于安慰剂。奥美拉唑（能显著抑制胃酸）和手术（加强抗反流机制）取得的良好效果表明，未来治疗可能需要采取更积极的方法。还需要在愈合阶段和维持治疗期间使用联合药物的更多研究。这些研究应与手术的长期结果进行比较。
