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本文引用的文献

1
Broad anti-HIV activity of the Oscillatoria agardhii agglutinin homologue lectin family.颤藻凝集素同源凝集素家族具有广泛的抗HIV活性。
J Antimicrob Chemother. 2014 Oct;69(10):2746-58. doi: 10.1093/jac/dku220. Epub 2014 Jun 25.
2
Protein backbone and sidechain torsion angles predicted from NMR chemical shifts using artificial neural networks.使用人工神经网络从 NMR 化学位移预测蛋白质主链和侧链扭转角。
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Structural insights into the anti-HIV activity of the Oscillatoria agardhii agglutinin homolog lectin family.蓝藻凝集素家族抗 HIV 活性的结构研究
J Biol Chem. 2012 Sep 28;287(40):33796-811. doi: 10.1074/jbc.M112.388579. Epub 2012 Aug 4.
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Algal lectins as potential HIV microbicide candidates.藻类凝集素作为有潜力的 HIV 微物杀菌剂候选物。
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Structural basis of the anti-HIV activity of the cyanobacterial Oscillatoria Agardhii agglutinin.蓝藻 Oscillatoria Agardhii 凝集素抗 HIV 活性的结构基础。
Structure. 2011 Aug 10;19(8):1170-81. doi: 10.1016/j.str.2011.05.010.
6
Novel fold and carbohydrate specificity of the potent anti-HIV cyanobacterial lectin from Oscillatoria agardhii.新型折叠结构和碳水化合物特异性：来自念珠藻的强效抗 HIV 蓝藻凝集素。
J Biol Chem. 2011 Jan 14;286(2):1588-97. doi: 10.1074/jbc.M110.173278. Epub 2010 Oct 19.
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Targeting the glycans of glycoproteins: a novel paradigm for antiviral therapy.靶向糖蛋白聚糖：抗病毒治疗的新范式
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8
Primary structure and carbohydrate binding specificity of a potent anti-HIV lectin isolated from the filamentous cyanobacterium Oscillatoria agardhii.从丝状蓝藻阿氏颤藻中分离出的一种强效抗HIV凝集素的一级结构和碳水化合物结合特异性。
J Biol Chem. 2007 Apr 13;282(15):11021-9. doi: 10.1074/jbc.M701252200. Epub 2007 Feb 21.
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来自阿氏颤藻的抗HIV凝集素的（1）H、（13）C和（15）N共振归属

(1)H, (13)C and (15)N resonance assignment of the anti-HIV lectin from Oscillatoria agardhii.

作者信息

Carneiro Marta G, Koharudin Leonardus M I, Griesinger Christian, Gronenborn Angela M, Lee Donghan

机构信息

Department for NMR-based Structural Biology, Max-Planck Institute for Biophysical Chemistry, Am Fassberg 11, 37077, Göttingen, Germany.

Department of Structural Biology, University of Pittsburgh School of Medicine, 1050 Biomedical Science Tower 3, 3501 5th Ave, Pittsburgh, PA, 15260, USA.

出版信息

Biomol NMR Assign. 2015 Oct;9(2):317-9. doi: 10.1007/s12104-015-9600-8. Epub 2015 Feb 14.

DOI:10.1007/s12104-015-9600-8
PMID:25680849
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4537409/
Abstract

Lectins from different sources are known to interfere with HIV infection. The anti-viral activity is mediated by binding to high mannose sugars present on the viral envelope, thereby inhibiting cell entry. The lectin from Oscillatoria agardhii agglutinin (OAA) specifically recognizes a unique substructure of high mannose sugars and exhibits broad anti-HIV activity. Here we report the assignment of backbone and side-chain (1)H, (13)C and (15)N resonances of free OAA.

摘要

已知来自不同来源的凝集素会干扰HIV感染。抗病毒活性是通过与病毒包膜上存在的高甘露糖糖结合来介导的，从而抑制细胞进入。来自颤藻凝集素（OAA）的凝集素特异性识别高甘露糖糖的独特亚结构，并表现出广泛的抗HIV活性。在此，我们报告了游离OAA的主链和侧链氢、碳-13和氮-15共振的归属。