Sobolev Boris, Sheehan Katie Jane, Kuramoto Lisa, Guy Pierre
School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada; Centre for Clinical Epidemiology and Evaluation, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC, Canada.
School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada; Centre for Clinical Epidemiology and Evaluation, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, BC, Canada.
Bone. 2015 Jun;75:72-6. doi: 10.1016/j.bone.2015.02.003. Epub 2015 Feb 12.
Secondary prevention often targets women who suffer from higher rates of second hip fracture than men, especially in the early years after first fracture. Yet, the occurrence of second hip fracture by certain times also depends on the death rate, which is higher in men than women. We compared the risk of sustaining second hip fracture by a certain time between women and men remaining alive at that time.
We retrieved 38,383 hospitalization records of patients aged 60 years or older, who were discharged alive after admission for hip fracture surgery between 1990 and 2005 in British Columbia, Canada. The outcome variable was the time to a subsequent hip fracture.
During ten years of follow-up, 2,902 (8%) patients sustained a second hip fracture, and 21,428 (56%) died before sustaining a second hip fracture. The risk of second hip fracture in the surviving post-fracture patients was higher in women than in men: 2% vs 2%, 5% vs 4%, 9% vs 7%, 15% vs 13%, and 35% vs 30% at 1, 2, 3, 5, and 10 years after initial trauma, respectively, crude OR=1.25 (95% CI: 1.13-1.39). However, the risk did not differ between women and men after adjustment, OR=1.09 (95% CI: 0.98-1.21).
The risk of second hip fracture persists for at least ten years among hip fracture survivors, and therefore secondary prevention should continue beyond an early post-fracture period. Women and men have similar risks of second hip fracture and both should be considered for secondary prevention.
二级预防通常针对髋部二次骨折发生率高于男性的女性,尤其是在首次骨折后的早期阶段。然而,到特定时间发生二次髋部骨折的情况也取决于死亡率,男性的死亡率高于女性。我们比较了在特定时间仍存活的女性和男性发生二次髋部骨折的风险。
我们检索了1990年至2005年期间在加拿大不列颠哥伦比亚省因髋部骨折手术入院后存活出院的60岁及以上患者的38383份住院记录。结局变量是至后续髋部骨折的时间。
在十年的随访期间,2902名(8%)患者发生了二次髋部骨折,21428名(56%)患者在发生二次髋部骨折前死亡。骨折后存活患者中二次髋部骨折的风险女性高于男性:分别在初次创伤后1、2、3、5和10年时,女性为2%、5%、9%、15%和35%,男性为2%、4%、7%、13%和30%,粗优势比=1.25(95%可信区间:1.13-1.39)。然而,调整后女性和男性之间的风险没有差异,优势比=1.09(95%可信区间:0.98-1.21)。
髋部骨折幸存者中二次髋部骨折的风险至少持续十年,因此二级预防应在骨折后早期之后继续进行。女性和男性发生二次髋部骨折的风险相似,两者都应考虑进行二级预防。