Komaki Alireza, Karimi Seyed Asaad, Salehi Iraj, Sarihi Abdolrahman, Shahidi Siamak, Zarei Mohammad
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran.
Pharmacol Biochem Behav. 2015 Apr;131:98-103. doi: 10.1016/j.pbb.2015.02.008. Epub 2015 Feb 14.
Cognitive function is impaired by imbalanced diet consumption. High-fat diet (HFD) induces oxidative stress and metabolic disorders, which results in neuronal damage and interferes with synaptic transmission and neurogenesis; hence, a decline in learning and memory. Antioxidants are believed to have positive effects on cognitive function. The objective of this study was to determine the relation between the chronic consumption of a HFD and antioxidants on passive avoidance learning (PAL) in male rats. Wistar rats were randomly assigned into the following five groups (N=6-8): Control group-consumed an ordinary diet; HFD group-received high-fat diets only; ANO group-received HFD plus antioxidants (vitamins C and E and astaxanthin (ASX)); RHFD group-received the restricted HFD (30% less than the HFD group); and RANO group-received restricted HFD plus antioxidants (30% less than the ANO group). Following 6months of controlled dietary condition as mentioned above, in each experimental group, the PAL was assessed using shuttle box apparatus. Our results showed that HFD caused a decrease in step through latency in the retention test (STLr) and increased the time spent in the dark compartment in the retention test (TDC) when compared to the control group. Antioxidant supplementation caused an increase in STLr and decrease in TDC when compared to the control group. Furthermore, RHFD and RANO had no significant effect on STLr and TDC compared with the control group. According to our results, HFD impairs PAL and the combination of vitamins C and E and astaxanthin improves PAL deficits in the HFD group.
不均衡的饮食摄入会损害认知功能。高脂饮食（HFD）会引发氧化应激和代谢紊乱，进而导致神经元损伤，并干扰突触传递和神经发生；因此，学习和记忆能力会下降。抗氧化剂被认为对认知功能有积极影响。本研究的目的是确定长期食用高脂饮食与抗氧化剂对雄性大鼠被动回避学习（PAL）的关系。将Wistar大鼠随机分为以下五组（N = 6 - 8）：对照组——食用普通饮食；高脂饮食组——仅接受高脂饮食；ANO组——接受高脂饮食加抗氧化剂（维生素C、维生素E和虾青素（ASX））；限制高脂饮食组——接受限制的高脂饮食（比高脂饮食组少30%）；限制高脂饮食加抗氧化剂组——接受限制的高脂饮食加抗氧化剂（比ANO组少30%）。在上述受控饮食条件下持续6个月后，在每个实验组中，使用穿梭箱装置评估PAL。我们的结果表明，与对照组相比，高脂饮食导致在记忆测试中的穿箱潜伏期（STLr）缩短，且在记忆测试中在暗箱中停留的时间（TDC）增加。与对照组相比，补充抗氧化剂使STLr增加，TDC减少。此外，与对照组相比，限制高脂饮食和限制高脂饮食加抗氧化剂对STLr和TDC没有显著影响。根据我们的结果，高脂饮食会损害PAL，而维生素C、维生素E和虾青素的组合可改善高脂饮食组的PAL缺陷。
