Department of Colorectal Surgery, University College Hospital Galway, Galway, Ireland.
Discipline of Surgery, National University of Ireland, Galway, Ireland.
Gastroenterol Res Pract. 2015;2015:194931. doi: 10.1155/2015/194931. Epub 2015 Jan 22.
Background. One-fifth of people who develop colorectal cancer (CRC) have a first-degree relative (FDR) also affected. There is a large disparity in guidelines for screening of relatives of patients with CRC. Herein we address awareness and uptake of family screening amongst patients diagnosed with CRC under age 60 and compare guidelines for screening. Study Design. Patients under age 60 who received surgical management for CRC between June 2009 and May 2012 were identified using pathology records and theatre logbooks. A telephone questionnaire was carried out to investigate family history and screening uptake among FDRs. Results. Of 317 patients surgically managed for CRC over the study period, 65 were under age 60 at diagnosis (8 deceased). The mean age was 51 (30-59). 66% had node positive disease. 25% had a family history of colorectal cancer in a FDR. While American and Canadian guidelines identified 100% of these patients as requiring screening, British guidelines advocated screening for only 40%. Of 324 FDRs, only 40.9% had been screened as a result of patient's diagnosis. Conclusions. Uptake of screening in FDRs of young patients with CRC is low. Increased education and uniformity of guidelines may improve screening uptake in this high-risk population.
五分之一患有结直肠癌（CRC）的人有一级亲属（FDR）也受到影响。对于 CRC 患者亲属的筛查指南存在很大差异。在此，我们针对年龄在 60 岁以下被诊断患有 CRC 的患者进行家庭筛查的意识和接受程度进行调查，并比较筛查指南。
通过病理记录和手术室日志，确定 2009 年 6 月至 2012 年 5 月期间接受 CRC 手术治疗的年龄在 60 岁以下的患者。通过电话问卷调查，调查 FDR 中的家族史和筛查接受情况。
在研究期间，接受 CRC 手术治疗的 317 名患者中，有 65 名患者在诊断时年龄在 60 岁以下（8 名死亡）。平均年龄为 51 岁（30-59 岁）。66%的患者存在淋巴结阳性疾病。25%的患者有 FDR 的结直肠癌家族史。尽管美国和加拿大的指南确定这些患者 100%需要进行筛查，但英国的指南仅主张对 40%的患者进行筛查。在 324 名 FDR 中，仅有 40.9%的人因患者的诊断而接受了筛查。
CRC 年轻患者的 FDR 筛查接受率较低。增加教育和指南的一致性可能会提高这一高危人群的筛查接受率。
