BinSaeed A A, Torchyan A A, AlOmair B N, AlQadhib N S, AlSuwayeh F M, Monshi F M, AlRumaih F I, AlQahtani S A, AlYousefi N, Al-Drees A
Prince Sattam Bin Abdul Aziz Research Chair of Epidemiology and Public Health, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Department of Family and Community Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Eur J Clin Nutr. 2015 Oct;69(10):1151-5. doi: 10.1038/ejcn.2014.286. Epub 2015 Feb 18.
BACKGROUND/OBJECTIVES: The objectives of our study were to determine possible factors associated with low vitamin D levels in medical students.
SUBJECTS/METHODS: A cross-sectional study was performed among 255 first- to fifth-year male undergraduate medical students of one of the major universities in Saudi Arabia. Serum 25-hydroxyvitamin D (25(OH)D) levels were measured using electrochemiluminiscence. Multiple logistic regression analysis was performed.
Majority of Saudi medical students (75.2%) had 25(OH)D levels <30 nmol/l, defined as risk for deficiency by the Institute of Medicine. Multivariate analysis showed that the odds of having 25(OH)D serum levels of ⩾ 30 nmol/l were seven times higher both in students who took vitamin D (odds ratio (OR)=7.2, 95% confidence interval (CI)=1.8-29.9, P=0.006) or multivitamin supplements (OR=6.9, 95% CI=1.7-27.3, P=0.006) within 1 year. Students with a history of vitamin D testing >1 year before the study or moderate/vigorous physical activity (PA) had 4.4 (OR=4.4, 95% CI=1.7-11.4, P=0.003) and 2.7-fold (OR=2.7, 95% CI=1.3-5.3, P=0.006) higher odds of having 25(OH)D levels ⩾ 30 nmol/l, respectively. There was no significant association between 25(OH)D serum levels and average time spent outdoors per day (P=0.369) and type of clothing (long-sleeved vs short-sleeved; P=0.800).
Vitamin D deficiency was highly prevalent in Saudi medical students. Modifiable factors such as vitamin D intake and PA could be targeted for intervention. Further studies with standardized laboratory measurements of 25(OH)D are needed to explore the role of vitamin D testing in behavioral change, which may lead to increased serum 25(OH)D levels.
背景/目的：我们研究的目的是确定与医学生维生素D水平低相关的可能因素。
对象/方法：对沙特阿拉伯一所主要大学的255名大一至大五的男性本科医学生进行了一项横断面研究。采用电化学发光法测量血清25-羟基维生素D（25(OH)D）水平。进行了多因素逻辑回归分析。
大多数沙特医学生（75.2%）的25(OH)D水平<30 nmol/l，医学研究所将此定义为缺乏风险。多因素分析显示，在1年内服用维生素D（优势比（OR）=7.2，95%置信区间（CI）=1.8-29.9，P=0.006）或复合维生素补充剂（OR=6.9，95%CI=1.7-27.3，P=0.006）的学生中，25(OH)D血清水平≥30 nmol/l的几率高出7倍。在研究前1年以上有维生素D检测史或进行中度/剧烈体育活动（PA）的学生中，25(OH)D水平≥30 nmol/l的几率分别高出4.4倍（OR=4.4，95%CI=1.7-11.4，P=0.003）和2.7倍（OR=2.7，95%CI=1.3-5.3，P=0.006）。25(OH)D血清水平与每天户外活动的平均时间（P=0.369）和服装类型（长袖与短袖；P=0.800）之间无显著关联。
维生素D缺乏在沙特医学生中非常普遍。维生素D摄入和体育活动等可改变因素可作为干预目标。需要进一步开展采用标准化实验室测量25(OH)D的研究，以探索维生素D检测在行为改变中的作用，这可能会提高血清25(OH)D水平。
