a Nutrition and Metabolism Group (SFB, JVW, PML), Centre for Public Health, Queen's University Belfast, Royal Victoria Hospital Site , Belfast , UK.
b Cancer Epidemiology and Health Services Research Group (CRC, MMC), Centre for Public Health, Queen's University Belfast, Royal Victoria Hospital Site , Belfast , UK.
Crit Rev Food Sci Nutr. 2017 Jul 3;57(10):1999-2008. doi: 10.1080/10408398.2012.724481.
The influence of dietary fat upon breast cancer mortality remains largely understudied despite extensive investigation into its influence upon breast cancer risk.
To conduct meta-analyses of studies to clarify the association between dietary fat and breast cancer mortality.
MEDLINE and EMBASE were searched for relevant articles published up to March 2012. Risk of all-cause or breast-cancer-specific death was evaluated by combining multivariable adjusted estimates comparing highest versus lowest categories of intake; and per 20 g increase in intake of total and/or saturated fat (g/day) using random-effects meta-analyses.
Fifteen prospective cohort studies investigating total fat and/or saturated fat intake (g/day) and breast cancer mortality were included. There was no difference in risk of breast-cancer-specific death (n = 6; HR = 1.14; 95% CI: 0.86, 1.52; p = 0.34) or all-cause death (n = 4; HR = 1.73; 95% CI: 0.82, 3.66; p = 0.15) for women in the highest versus lowest category of total fat intake. Breast-cancer-specific death (n = 4; HR = 1.51; 95% CI: 1.09, 2.09; p < 0.01) was higher for women in the highest versus lowest category of saturated fat intake.
These meta-analyses have shown that saturated fat intake negatively impacts upon breast cancer survival.
尽管大量研究表明脂肪摄入会影响乳腺癌的发病风险，但饮食脂肪对乳腺癌死亡率的影响仍未得到充分研究。
通过荟萃分析来阐明饮食脂肪与乳腺癌死亡率之间的关系。
检索 MEDLINE 和 EMBASE 数据库，以获取截至 2012 年 3 月发表的相关文章。通过合并多变量调整后的最高与最低摄入量组间比较的估计值，评估全因或乳腺癌特异性死亡的风险；通过随机效应荟萃分析，评估总脂肪和/或饱和脂肪（g/天）每增加 20 g 的风险。
纳入了 15 项前瞻性队列研究，这些研究调查了总脂肪和/或饱和脂肪（g/天）摄入量与乳腺癌死亡率之间的关系。在最高与最低总脂肪摄入量组间，乳腺癌特异性死亡（n = 6；HR = 1.14；95%CI：0.86，1.52；p = 0.34）或全因死亡（n = 4；HR = 1.73；95%CI：0.82，3.66；p = 0.15）的风险没有差异。在最高与最低饱和脂肪摄入量组间，乳腺癌特异性死亡（n = 4；HR = 1.51；95%CI：1.09，2.09；p < 0.01）的风险更高。
这些荟萃分析表明，饱和脂肪摄入会对乳腺癌的生存产生负面影响。
