Carter Stephen J, Herron Robert L, Akers S Zeb, Bishop Phillip A
Department of Kinesiology, University of Alabama , Tuscaloosa , Alabama .
Int J Hyperthermia. 2015 Jun;31(4):319-24. doi: 10.3109/02656736.2014.999721. Epub 2015 Feb 20.
Acetylsalicylic acid (ASA), aspirin, exerts potent systemic effects that may interfere with normal thermo-effector responses. We investigated the influence of commonly ingested ASA doses on measures of skin blood flow (SkBF) and local sweat rate (SR) during whole-body, passive heat stress. Seven male participants completed counter-balanced trials to compare ASA treatments (single dose 325 mg or 4 consecutive days 81 mg (4-d 81 mg)) to control (no ASA). Laser-Doppler flowmetry provided an index of SkBF. A ventilated capsule measured local sweat rate via capacitance hygrometry. Mean body temperature ([Formula: see text]) was increased by 1 °C above baseline using a water-perfused suit. [Formula: see text] was similar at the onset of cutaneous vasodilation among trials. Cutaneous vascular conductance, expressed as a percentage change from baseline, was not different among trials. Additionally, [Formula: see text] at the onset of local SR and SR sensitivity did not differ among trials. While ASA has previously been shown to influence SkBF during heat stress, it is possible our cohort's relatively young age may have contributed to our dissimilar results.
乙酰水杨酸（ASA），即阿司匹林，具有强大的全身效应，可能会干扰正常的体温调节反应。我们研究了在全身被动热应激期间，常用剂量的ASA对皮肤血流量（SkBF）和局部出汗率（SR）测量值的影响。七名男性参与者完成了平衡试验，以比较ASA治疗（单次剂量325毫克或连续4天每天81毫克（4天81毫克组））与对照组（无ASA）。激光多普勒血流仪提供了SkBF的指标。一个通风胶囊通过电容湿度测定法测量局部出汗率。使用水灌注服使平均体温（[公式：见原文]）比基线升高1°C。在各试验中，皮肤血管舒张开始时的[公式：见原文]相似。以相对于基线的百分比变化表示的皮肤血管传导率在各试验中无差异。此外，在局部出汗率和出汗率敏感性开始时的[公式：见原文]在各试验中也无差异。虽然先前已证明ASA在热应激期间会影响SkBF，但我们研究对象相对年轻的年龄可能是导致我们结果不同的原因。
