Rosenthal Martin, Gabrielli Andrea, Moore Frederick
Division of Acute Care Surgery, Department of Surgery, University of Florida College of Medicine, Gainesville, FL, USA -
Minerva Anestesiol. 2016 Jan;82(1):84-96. Epub 2015 Feb 20.
Multiple organ failure (MOF) is an evolving pathologic phenotype that plagues intensive care units globally. This manuscript aims to depict the evolution of single organ failure through multiple organ failure, ending in the newest phenotype called persistent inflammation, immunosuppression, catabolism syndrome (PICS). Among the other MOF phenotypes discussed are systemic inflammatory response syndrome (SIRS) and compensatory anti-inflammatory response syndrome. Along with a review of the four phenotypes of MOF there is a review of the current literature on nutritional supplementation. Discussed in these sections are possible etiologies for the various progression of MOF, total enteral nutrition (TPN) versus early enteral nutrition (EEN), early versus late parenteral nutrition, glycemic control, and new enteral formulas. Finally, as the newest phenotype, PICS, has evolved we try to make inferences from similar pathologic states to recommend nutritional support that has proven beneficial.
多器官功能衰竭（MOF）是一种不断演变的病理表型，困扰着全球的重症监护病房。本文旨在描述单器官功能衰竭通过多器官功能衰竭的演变过程，最终发展为最新的表型——持续性炎症、免疫抑制、分解代谢综合征（PICS）。讨论的其他多器官功能衰竭表型包括全身炎症反应综合征（SIRS）和代偿性抗炎反应综合征。除了对多器官功能衰竭的四种表型进行综述外，还对当前关于营养补充的文献进行了综述。这些章节讨论了多器官功能衰竭各种进展的可能病因、全肠内营养（TPN）与早期肠内营养（EEN）、早期与晚期肠外营养、血糖控制以及新的肠内配方。最后，随着最新表型PICS的演变，我们试图从类似的病理状态中进行推断，以推荐已被证明有益的营养支持。
