Gligić A, Obradović M, Stojanović R, Vujosević N, Ovcarić A, Frusic M, Gibbs C J, Calisher C H, Gajdusek D C
Institute of Immunobiology and Virology Torlak, Belgrade, Yugoslavia.
Am J Trop Med Hyg. 1989 Jul;41(1):102-8.
An epidemic of hemorrhagic fever with renal syndrome (HFRS) occurred in Yugoslavia May-November 1986; all Republics and Provinces were involved. Serum samples were received from 260 of 276 persons with symptoms clinically compatible with a diagnosis of HFRS. Presumptive infection with a hantavirus was determined serologically for 161 of these. Many patients with serious clinical pictures, including severe renal insufficiency and shock, were hospitalized; 11 died. Indirect fluorescent antibody tests with antigens of 4 hantaviruses (Hantaan, Fojnica, Puumala, and the Vranica strain of Puumala virus) showed that greater than 1 serotype was circulating during this epidemic. Hantavirus antigens were detected in the lungs of 86 of 302 (28.5%) wild-caught small mammals.
1986年5月至11月，南斯拉夫发生了肾综合征出血热（HFRS）疫情，所有共和国和省份均有涉及。从276名临床症状与HFRS诊断相符的患者中采集了血清样本，其中260份样本被接收。通过血清学检测确定其中161人可能感染了汉坦病毒。许多出现严重临床症状（包括严重肾功能不全和休克）的患者住院治疗，11人死亡。用4种汉坦病毒（汉滩病毒、福伊尼察病毒、普马拉病毒以及普马拉病毒的弗拉尼察毒株）抗原进行的间接荧光抗体试验表明，此次疫情期间有不止1种血清型在传播。在302只野生捕获的小型哺乳动物中，有86只（28.5%）的肺部检测到了汉坦病毒抗原。
