Schüttler J, Kloos S, Schwilden H, Stoeckel H
Institut für Anästhesiologie, Rheinische, Friedrich-Wilhelms-Universität Bonn, Federal Republic of Germany.
Anaesthesia. 1988 Mar;43 Suppl:2-7. doi: 10.1111/j.1365-2044.1988.tb09059.x.
The combination of propofol and alfentanil was administered to 20 patients for total intravenous anaesthesia during general surgery. The infusion rates for both drugs were controlled by microprocessors in order to institute constant blood levels adapted to the patients' varying needs. The mean blood level of propofol required for adequate hypnosis during anaesthesia was 2.42 micrograms/ml (SD 0.43). Awakening occurred 7.9 minutes (SD 3.4) after the end of the infusion, at a propofol blood level of 1.59 micrograms/ml (SD 0.34). The plasma level of alfentanil was 285 ng/ml (SD 72) during major noxious stimulation and 148 ng/ml (SD 56) during minor stimulation. The computer-assisted infusions showed a measured/predicted ratio of 1.01 (SD 0.28) for alfentanil and 0.88 (SD 0.22) for propofol. This indicates that the administration device used in this study is reasonably reliable. The technique of total intravenous anaesthesia was characterised by a smooth induction without significant haemodynamic alterations, by good control during anaesthesia and by a very fast recovery without major side effects.
在普通外科手术期间，对20例患者采用丙泊酚和阿芬太尼联合进行全静脉麻醉。两种药物的输注速率由微处理器控制，以维持适应患者不同需求的恒定血药浓度。麻醉期间达到充分催眠所需的丙泊酚平均血药浓度为2.42微克/毫升（标准差0.43）。输注结束后7.9分钟（标准差3.4）患者苏醒，此时丙泊酚血药浓度为1.59微克/毫升（标准差0.34）。在强刺激期间阿芬太尼血浆浓度为285纳克/毫升（标准差72），在弱刺激期间为148纳克/毫升（标准差56）。计算机辅助输注显示，阿芬太尼的实测/预测比值为1.01（标准差0.28），丙泊酚为0.88（标准差0.22）。这表明本研究中使用的给药装置相当可靠。全静脉麻醉技术的特点是诱导平稳，无明显血流动力学改变，麻醉期间控制良好，恢复非常迅速且无严重副作用。
