Nouri Saeed, Sharif Mohammad Reza, Tabatabaei Fatemeh, Farokhi Shima
Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
Trauma Research Center, Kashan University of Medical Sciences, Kashan, IR Iran.
Nurs Midwifery Stud. 2014 Sep;3(3):e22063. doi: 10.17795/nmsjournal22063. Epub 2014 Sep 20.
Despite all progresses in surgical science, bleeding caused by traffic accidents is still a challenge for surgeons to save patients' lives. Therefore, introducing an effective method to control external bleeding is an important research priority.
This study aimed to compare haemostatic effect of zinc chloride and simple suturing to control external bleeding.
In this animal model study, 60 male Wistar rats were used. An incision (two cm in length and half a cm in depth) was made on shaved back of rats. The hemostasis time was measured once using zinc chloride with different concentrations (5%, 10%, 15%, 25%, and 50%) and then using simple suturing. Skin tissue was assessed for pathological changes. Due to abnormal distribution of variables in Kolmogorov-Smirnov test, the data was analyzed using Kruskal-Wallis test Mann-Whitney U tests.
In all the groups, complete hemostasis occurred. Hemostasis times of different concentrations of zinc chloride were significantly less than that of the control group (P < 0.001).
Zinc chloride was effective to control external bleeding in rats.
尽管外科学取得了诸多进展，但交通事故导致的出血仍是外科医生挽救患者生命面临的一项挑战。因此，引入一种有效的控制外出血方法是一项重要的研究重点。
本研究旨在比较氯化锌与单纯缝合控制外出血的止血效果。
在这项动物模型研究中，使用了60只雄性Wistar大鼠。在大鼠背部剃毛处做一个切口（长2厘米，深0.5厘米）。分别使用不同浓度（5%、10%、15%、25%和50%）的氯化锌然后使用单纯缝合测量一次止血时间。对皮肤组织进行病理变化评估。由于在Kolmogorov-Smirnov检验中变量分布异常，数据采用Kruskal-Wallis检验和Mann-Whitney U检验进行分析。
所有组均实现完全止血。不同浓度氯化锌的止血时间显著短于对照组（P < 0.001）。
氯化锌对控制大鼠外出血有效。
