使用硫酸铁控制肝脏出血。
Use of ferric sulfate to control hepatic bleeding.
作者信息
Nouri Saeed, Sharif Mohammad Reza
机构信息
Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, IR Iran.
Trauma Research Center, Kashan University of Medical Sciences, Kashan, IR Iran.
出版信息
Trauma Mon. 2015 Feb;20(1):e25257. doi: 10.5812/traumamon.25257. Epub 2015 Jan 1.
BACKGROUND
Controlling parenchymal hemorrhage, especially in liver parenchyma, despite all the progress in surgical science, is still one of the challenges surgeons face. Therefore, search for an effective method to control hepatic bleeding is an important research priority.
OBJECTIVES
This study attempted to determine the haemostatic effect of ferric sulfate and compare it with the standard method (suturing technique).
MATERIALS AND METHODS
In this animal model study, 60 male Wistar rats were used. An incision (2 cm in length and 1/2 cm in depth) was made on each rat's liver and the hemostasis time was measured using ferric sulfate with different concentrations (5%, 10%, 15%, 25%, and 50%) and then using simple suturing. The liver tissue was assessed for pathological changes.
RESULTS
In all the groups, complete hemostasis occurred. Hemostasis times of different concentrations of ferric sulfate were significantly less than those of the control group (P < 0.001).
CONCLUSIONS
Ferric sulfate was effective in controlling hepatic bleeding in rats.
背景
尽管外科学取得了诸多进展，但控制实质内出血，尤其是肝实质内出血，仍是外科医生面临的挑战之一。因此，寻找一种有效的控制肝出血的方法是一项重要的研究重点。
目的
本研究试图确定硫酸铁的止血效果，并将其与标准方法（缝合技术）进行比较。
材料与方法
在这项动物模型研究中，使用了60只雄性Wistar大鼠。在每只大鼠的肝脏上做一个切口（长2厘米，深1/2厘米），先用不同浓度（5%、10%、15%、25%和50%）的硫酸铁测量止血时间，然后使用简单缝合测量止血时间。对肝组织进行病理变化评估。
结果
在所有组中均实现了完全止血。不同浓度硫酸铁的止血时间显著短于对照组（P < 0.001）。
结论
硫酸铁在控制大鼠肝出血方面有效。
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