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颅底凹陷症:病例报告与文献复习。

Basilar Invagination: Case Report and Literature Review.

机构信息

Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Department of Neurological Surgery, Oregon Health Sciences University, Portland, Oregon, USA.

出版信息

World Neurosurg. 2015 Jun;83(6):1180.e7-11. doi: 10.1016/j.wneu.2015.02.007. Epub 2015 Feb 18.

Abstract

BACKGROUND

Basilar invagination is a rare clinical condition characterized by upward protrusion of the odontoid process into the intracranial space, leading to bulbomedullary compression. It is often encountered in adults with rheumatoid arthritis. Transoral microscopic or endonasal endoscopic decompression may be pursued, with or without posterior fixation. We present a case of basilar invagination with C1-C2 autofusion and discuss an algorithm for choice of anterior versus posterior approaches.

CASE DESCRIPTION

A 47-year-old woman with rheumatoid arthritis presented with severe occipital and cervical pain, dysphagia, hoarseness, and arm paresthesias. Findings on magnetic resonance imaging revealed moderate cranial settling with the odontoid indenting the ventral medulla but no posterior compression. Computed tomography demonstrated bony fusion at C1-C2 without lateral sag. Given autofusion of C1-C2 in proper occipitocervical alignment and the absence of posterior compression, the patient underwent endoscopic endonasal odontoidectomy without further posterior fusion, with satisfactory resolution of symptoms.

CONCLUSION

Endoscopic endonasal odontoidectomy offers a safe and effective method for anterior decompression of basilar invagination. Preoperative assessment for existing posterior fusion, absence of posterior compression, and preservation of the anterior C1 ring during operative decompression help stratify the need for lone anterior approach versus a combined anterior and posterior treatment.

摘要

背景

颅底凹陷症是一种罕见的临床病症,其特征为齿状突向上突入颅腔,导致延髓和延髓受压。这种病症常见于患有类风湿性关节炎的成年人。可以通过经口显微镜或经鼻内镜减压术来治疗,可单独采用,也可联合后路固定。我们报告了一例伴有 C1-C2 自融合的颅底凹陷症病例,并讨论了选择前路或后路方法的算法。

病例描述

一位 47 岁的类风湿关节炎女性患者出现严重的枕颈疼痛、吞咽困难、声音嘶哑和手臂感觉异常。磁共振成像结果显示颅底下沉,齿状突压迫脊髓腹侧,但无后向压迫。计算机断层扫描显示 C1-C2 处存在骨性融合,但无侧方移位。鉴于 C1-C2 自融合且枕颈排列适当,且无后向压迫,患者接受了内镜经鼻齿状突切除术,无需进一步后路融合,症状得到了满意的缓解。

结论

内镜经鼻齿状突切除术为颅底凹陷症的前路减压提供了一种安全有效的方法。术前评估是否存在后路融合、有无后向压迫以及在手术减压过程中保持前环 C1 的完整性有助于分层决定是否仅采用前路方法还是联合前路和后路治疗。

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