早年生活应激会增加成年期小胶质细胞的运动性。
Early-life stress increases the motility of microglia in adulthood.
作者信息
Takatsuru Yusuke, Nabekura Junichi, Ishikawa Tatsuya, Kohsaka Shin-ichi, Koibuchi Noriyuki
机构信息
Department of Integrative Physiology, Gunma University Graduate School of Medicine, Maebashi, Gunma, 371-8511, Japan,
出版信息
J Physiol Sci. 2015 Mar;65(2):187-94. doi: 10.1007/s12576-015-0361-z. Epub 2015 Feb 10.
Early-life stress may cause several neuropsychological disorders in adulthood. Such disorders may be induced as a result of instability of neuronal circuits and/or synaptic formation. However, the mechanisms underlying such instability have not yet been clearly understood. We previously reported that the mushroom spine in the somatosensory cortex (SSC) is unstable in early-life stressed mice not only in the juvenile stage but also in adulthood. In this study, we measured the number and motility of microglial processes in early-life stressed mice to understand the mechanism further. We found that the number and motility of filopodia-like protrusions of microglial processes tended to increase in the SSC of early-life stressed mice. Interestingly, the motility of protrusions correlated significantly with the nociceptive threshold level measured by the von Frey test. These results indicated that the activity of microglia affected the neuronal function in early-life stressed mice.
早年生活应激可能会在成年期引发多种神经心理障碍。此类障碍可能是由于神经回路和/或突触形成的不稳定所致。然而，这种不稳定背后的机制尚未完全明确。我们之前报道过，早年生活应激小鼠体感皮层（SSC）中的蘑菇状棘不仅在幼年阶段而且在成年期都不稳定。在本研究中，我们测量了早年生活应激小鼠小胶质细胞突起的数量和运动性，以进一步了解其机制。我们发现，早年生活应激小鼠SSC中丝状伪足样突起的数量和运动性有增加的趋势。有趣的是，突起的运动性与通过von Frey试验测得的伤害性感受阈值水平显著相关。这些结果表明，小胶质细胞的活性影响了早年生活应激小鼠的神经元功能。
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