Nogueira E, Klimek F, Weber E, Bannasch P
Institut für Experimentelle Pathologie, Deutsches Krebsforschungszentrum, Im Neuenheimer, Heidelberg, Federal Republic of Germany.
Virchows Arch B Cell Pathol Incl Mol Pathol. 1989;57(5):275-83. doi: 10.1007/BF02899092.
The renal tubular segment from which clear cell tumors originate was investigated in the kidneys of rats treated with N-nitrosomorpholine. This tumor type, which in the rat closely resembles that in man, is made up of clear and granular acidophilic cells and arises from tubules lined by clear cells. The tubular origin of the tumors was established in serial sections by demonstrating connections between both clear cell tumors and tubules lined by clear cells, and renal tubules of normal appearance. In 45 clear cell lesions (17 tumors and 28 tubules) one or more such connections were identified which belonged to the collecting system. In accordance with their localisation in the kidney, the clear cell lesions were connected predominantly to tubules of the cortical collecting system and occasionally to outer medullary collecting ducts. As previously reported, oncocytic tubules and microoncocytomas were observed to originate from the same portions of the collecting system. Rarely, microadenomas and tubules consisting of both oncocytes and clear or granular acidophilic cells were also observed in the kidneys studied.
在接受N-亚硝基吗啉处理的大鼠肾脏中，对透明细胞肿瘤起源的肾小管节段进行了研究。这种在大鼠中与人类的肿瘤非常相似的肿瘤类型，由透明和颗粒状嗜酸性细胞组成，起源于由透明细胞衬里的小管。通过证明透明细胞肿瘤与由透明细胞衬里的小管以及外观正常的肾小管之间的连接，在连续切片中确定了肿瘤的小管起源。在45个透明细胞病变（17个肿瘤和28个小管）中，发现了一个或多个属于集合系统的此类连接。根据它们在肾脏中的定位，透明细胞病变主要与皮质集合系统的小管相连，偶尔与外髓集合管相连。如先前报道，观察到嗜酸性细胞小管和微嗜酸性细胞瘤起源于集合系统的相同部分。在所研究的肾脏中，还很少观察到微腺瘤以及由嗜酸性细胞与透明或颗粒状嗜酸性细胞组成的小管。
