Nogueira E, Bannasch P
Institut für Experimentelle Pathologie, Deutsches Krebsforschungszentrum, Heidelberg, Federal Republic of Germany.
Lab Invest. 1988 Sep;59(3):337-43.
The cellular origin of the rat renal oncocytoma was studied by light and electron microscopy in rats treated with N-nitrosomorpholine. The oncocytomas which appeared as small solid masses or cysts developed from tubules lined by oncocytes. Rats treated with N-nitrosomorpholine showed a number of oncocytomas and many oncocytic tubules, the incidence of which increased with time. A small number of oncocytic tubules but no oncocytomas were observed in the oldest control rats. Two major types of oncocytes were detected in the oncocytic lesions. Whereas some oncocytes contain only small round mitochondria, most oncocytes exhibited both small and unusually large pleomorphic mitochondria. The tubular origin of the oncocytic lesions was established precisely in serial sections. Numerous transitions of both oncocytomas and oncocytic tubules into renal tubules of normal appearance indicated that oncocytic lesions developed frequently from the cortical collecting duct system, including the connecting tubule, and occasionally from the outer medullary collecting duct. Mitochondrial changes similar to those of fully developed oncocytes were recognized in principal and intercalated cells of these segments, indicating the involvement of these cell types in the genesis of the renal oncocytoma.
通过光学显微镜和电子显微镜研究了用N-亚硝基吗啉处理的大鼠肾嗜酸细胞瘤的细胞起源。作为小实体肿块或囊肿出现的嗜酸细胞瘤由嗜酸细胞衬里的小管发展而来。用N-亚硝基吗啉处理的大鼠出现了许多嗜酸细胞瘤和许多嗜酸细胞小管，其发生率随时间增加。在最老的对照大鼠中观察到少量嗜酸细胞小管但没有嗜酸细胞瘤。在嗜酸细胞病变中检测到两种主要类型的嗜酸细胞。一些嗜酸细胞仅含有小的圆形线粒体，而大多数嗜酸细胞既表现出小的又表现出异常大的多形性线粒体。在连续切片中精确确定了嗜酸细胞病变的小管起源。许多嗜酸细胞瘤和嗜酸细胞小管向正常外观的肾小管的转变表明，嗜酸细胞病变经常从包括连接小管在内的皮质集合管系统发展而来，偶尔也从外髓集合管发展而来。在这些节段的主细胞和闰细胞中识别出与完全发育的嗜酸细胞相似的线粒体变化，表明这些细胞类型参与了肾嗜酸细胞瘤的发生。
