• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

丹酚酸通过改善血流特性减轻大鼠急性一氧化碳中毒后的海马损伤。

Salvianolic acids attenuate rat hippocampal injury after acute CO poisoning by improving blood flow properties.

作者信息

Guan Li, Zhang Yan-Lin, Li Zong-Yang, Zhu Ming-Xia, Yao Wei-Juan, Zhao Jin-Yuan

机构信息

Research Center of Occupational Medicine, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing 100191, China.

Hemorheology Center, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xue Yuan Road, Haidian District, Beijing 100191, China.

出版信息

Biomed Res Int. 2015;2015:526483. doi: 10.1155/2015/526483. Epub 2015 Feb 1.

DOI:10.1155/2015/526483
PMID:25705671
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4331406/
Abstract

Carbon monoxide (CO) poisoning causes the major injury and death due to poisoning worldwide. The most severe damage via CO poisoning is brain injury and mortality. Delayed encephalopathy after acute CO poisoning (DEACMP) occurs in forty percent of the survivors of acute CO exposure. But the pathological cause for DEACMP is not well understood. And the corresponding therapy is not well developed. In order to investigate the effects of salvianolic acid (SA) on brain injury caused by CO exposure from the view point of hemorheology, we employed a rat model and studied the dynamic of blood changes in the hemorheological and coagulative properties over acute CO exposure. Compared with the groups of CO and 20% mannitol + CO treatments, the severe hippocampal injury caused by acute CO exposure was prevented by SA treatment. These protective effects were associated with the retaining level of hematocrit (Hct), plasma viscosity, fibrinogen, whole blood viscosities and malondialdehyde (MDA) levels in red blood cells (RBCs). These results indicated that SA treatment could significantly improve the deformation of erythrocytes and prevent the damage caused by CO poisoning. Meanwhile, hemorheological indexes are good indicators for monitoring the pathological dynamic after acute CO poisoning.

摘要

一氧化碳（CO）中毒是全球中毒导致重大伤亡的主要原因。CO中毒造成的最严重损害是脑损伤和死亡。急性CO中毒后迟发性脑病（DEACMP）发生于40%的急性CO中毒幸存者中。但DEACMP的病理原因尚不清楚，相应的治疗方法也不完善。为了从血液流变学角度研究丹酚酸（SA）对CO暴露所致脑损伤的影响，我们采用大鼠模型，研究了急性CO暴露过程中血液流变学和凝血特性的动态变化。与CO组和20%甘露醇+CO治疗组相比，SA治疗可预防急性CO暴露所致的严重海马损伤。这些保护作用与血细胞比容（Hct）、血浆粘度、纤维蛋白原、全血粘度以及红细胞（RBC）中丙二醛（MDA）水平的维持程度有关。这些结果表明，SA治疗可显著改善红细胞变形能力，预防CO中毒所致损伤。同时，血液流变学指标是监测急性CO中毒后病理动态变化的良好指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e7f/4331406/a79754776822/BMRI2015-526483.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e7f/4331406/0f24a4cad18d/BMRI2015-526483.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e7f/4331406/c6b34c022f85/BMRI2015-526483.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e7f/4331406/82377662ca6a/BMRI2015-526483.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e7f/4331406/e760ec732116/BMRI2015-526483.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e7f/4331406/69d3d7fe2038/BMRI2015-526483.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e7f/4331406/a79754776822/BMRI2015-526483.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e7f/4331406/0f24a4cad18d/BMRI2015-526483.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e7f/4331406/c6b34c022f85/BMRI2015-526483.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e7f/4331406/82377662ca6a/BMRI2015-526483.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e7f/4331406/e760ec732116/BMRI2015-526483.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e7f/4331406/69d3d7fe2038/BMRI2015-526483.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e7f/4331406/a79754776822/BMRI2015-526483.006.jpg

相似文献

1
Salvianolic acids attenuate rat hippocampal injury after acute CO poisoning by improving blood flow properties.丹酚酸通过改善血流特性减轻大鼠急性一氧化碳中毒后的海马损伤。
Biomed Res Int. 2015;2015:526483. doi: 10.1155/2015/526483. Epub 2015 Feb 1.
2
Hemorheological changes in cerebral circulation of rabbits with acute carbon monoxide poisoning.兔急性一氧化碳中毒时脑循环血液流变学的变化。
Clin Hemorheol Microcirc. 2009;43(4):271-82. doi: 10.3233/CH-2009-1239.
3
Induction of heme oxygenase-1 with hemin attenuates hippocampal injury in rats after acute carbon monoxide poisoning.用氯化血红素诱导血红素加氧酶-1可减轻大鼠急性一氧化碳中毒后的海马损伤。
Toxicology. 2009 Aug 3;262(2):146-52. doi: 10.1016/j.tox.2009.06.001. Epub 2009 Jun 9.
4
Acute carbon monoxide poisoning alters hemorheological parameters in human.急性一氧化碳中毒会改变人体的血液流变学参数。
Clin Hemorheol Microcirc. 2016;61(4):591-7. doi: 10.3233/CH-141919.
5
[Establishment of delayed encephalopathy rat model of carbon monoxide poisoning].[一氧化碳中毒迟发性脑病大鼠模型的建立]
Zhonghua Yi Xue Za Zhi. 2002 Dec 10;82(23):1645-8.
6
[Dynamic changes of hemorheology in rats after carbon monoxide poisoning].[一氧化碳中毒大鼠血液流变学的动态变化]
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi. 2010 Dec;28(12):885-90.
7
The effect of carbon monoxide poisoning on hemorheological parameters in rats and the alterations in these parameters in response to three kinds of treatments.一氧化碳中毒对大鼠血液流变学参数的影响及三种治疗方法对这些参数的改变。
Clin Hemorheol Microcirc. 2010;44(2):87-96. doi: 10.3233/CH-2010-1254.
8
Hydrogen gas protects against delayed encephalopathy after acute carbon monoxide poisoning in a rat model.氢气对大鼠急性一氧化碳中毒后迟发性脑病具有保护作用。
Neurol Res. 2020 Jan;42(1):22-30. doi: 10.1080/01616412.2019.1685064. Epub 2019 Nov 3.
9
Inhibition of ROCK2 kinase activity improved behavioral deficits and reduced neuron damage in a DEACMP rat model.抑制 ROCK2 激酶活性可改善 DEACMP 大鼠模型的行为缺陷并减少神经元损伤。
Brain Res Bull. 2022 Mar;180:24-30. doi: 10.1016/j.brainresbull.2021.12.018. Epub 2022 Jan 3.
10
The nicotinic cholinergic system is affected in rats with delayed carbon monoxide encephalopathy.在患有迟发性一氧化碳脑病的大鼠中，烟碱能胆碱能系统受到影响。
Neurosci Lett. 2014 May 21;569:33-7. doi: 10.1016/j.neulet.2014.03.054. Epub 2014 Apr 2.

引用本文的文献

1
Reciprocal regulation of GPNMB/HIF-1α for Inhibition of neuronal ferroptosis in delayed encephalopathy after acute carbon monoxide poisoning.GPNMB/HIF-1α相互调节对急性一氧化碳中毒后迟发性脑病中神经元铁死亡的抑制作用
Acta Neuropathol Commun. 2025 Jul 14;13(1):154. doi: 10.1186/s40478-025-02069-x.
2
Abnormalities of Hippocampal Subfields in Individuals With Acute Carbon Monoxide Poisoning.急性一氧化碳中毒个体海马亚区的异常
CNS Neurosci Ther. 2025 Jun;31(6):e70482. doi: 10.1111/cns.70482.
3
The Relationship between Cadherin Polymorphisms and the Risk of Delayed Encephalopathy after Acute Carbon Monoxide Poisoning in the Chinese Han Population.

本文引用的文献

1
Cardiovascular effects of salvianolic Acid B.丹酚酸 B 的心血管作用。
Evid Based Complement Alternat Med. 2013;2013:247948. doi: 10.1155/2013/247948. Epub 2013 Jun 10.
2
Detection of gray matter damage using brain MRI and SPECT in carbon monoxide intoxication: a comparison study with neuropsychological correlation.应用脑 MRI 和 SPECT 检测一氧化碳中毒患者的灰质损害：与神经心理学相关性的比较研究。
Clin Nucl Med. 2013 Feb;38(2):e53-9. doi: 10.1097/RLU.0b013e31827082a7.
3
By improving regional cortical blood flow, attenuating mitochondrial dysfunction and sequential apoptosis galangin acts as a potential neuroprotective agent after acute ischemic stroke.
中国人群中钙黏蛋白多态性与急性一氧化碳中毒后迟发性脑病风险的关系。
Behav Neurol. 2022 Jan 30;2022:3155703. doi: 10.1155/2022/3155703. eCollection 2022.
通过改善区域皮质血流、减轻线粒体功能障碍和顺序细胞凋亡，姜黄素有作为急性缺血性脑卒中后潜在神经保护剂的作用。
Molecules. 2012 Nov 9;17(11):13403-23. doi: 10.3390/molecules171113403.
4
Analytical performance evaluation of the scanning capillary tube viscometer for measurement of whole blood viscosity.扫描毛细管黏度计测量全血黏度的分析性能评估。
Clin Biochem. 2013 Jan;46(1-2):139-42. doi: 10.1016/j.clinbiochem.2012.10.015. Epub 2012 Oct 22.
5
Diffusion-weighted imaging improves prediction in cognitive outcome and clinical phases in patients with carbon monoxide intoxication.一氧化碳中毒患者的弥散加权成像改善认知预后和临床分期的预测。
Neuroradiology. 2013 Jan;55(1):107-15. doi: 10.1007/s00234-012-1102-0. Epub 2012 Oct 24.
6
Alterations of haemorheological parameters in patients with peripheral arterial disease.外周动脉疾病患者血液流变学参数的变化。
Clin Hemorheol Microcirc. 2013 Jan 1;55(2):271-6. doi: 10.3233/CH-2012-1633.
7
Comparison of novel risk markers for improvement in cardiovascular risk assessment in intermediate-risk individuals.新型风险标志物在改善中危人群心血管风险评估中的比较。
JAMA. 2012 Aug 22;308(8):788-95. doi: 10.1001/jama.2012.9624.
8
A review of disaster-related carbon monoxide poisoning: surveillance, epidemiology, and opportunities for prevention.灾难相关的一氧化碳中毒综述：监测、流行病学和预防机会。
Am J Public Health. 2012 Oct;102(10):1957-63. doi: 10.2105/AJPH.2012.300674. Epub 2012 Aug 16.
9
Disorders of erythrocyte structure and function in hypertensive patients.高血压患者红细胞结构和功能障碍。
Med Sci Monit. 2012 Aug;18(8):BR331-336. doi: 10.12659/msm.883265.
10
Effect of suspending viscosity on red blood cell dynamics and blood flows in microvessels.悬浮粘度对微血管中红细胞动力学和血流的影响。
Microcirculation. 2011 Oct;18(7):562-73. doi: 10.1111/j.1549-8719.2011.00116.x.