Sirály Enikő, Szabó Ádám, Szita Bernadett, Kovács Vivienne, Fodor Zsuzsanna, Marosi Csilla, Salacz Pál, Hidasi Zoltán, Maros Viktor, Hanák Péter, Csibri Éva, Csukly Gábor
Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary.
Semmelweis University, Magnetic Resonance Imaging Research Center, Budapest, Hungary.
PLoS One. 2015 Feb 23;10(2):e0117918. doi: 10.1371/journal.pone.0117918. eCollection 2015.
It is anticipated that current and future preventive therapies will likely be more effective in the early stages of dementia, when everyday functioning is not affected. Accordingly the early identification of people at risk is particularly important. In most cases, when subjects visit an expert and are examined using neuropsychological tests, the disease has already been developed. Contrary to this cognitive games are played by healthy, well functioning elderly people, subjects who should be monitored for early signs. Further advantages of cognitive games are their accessibility and their cost-effectiveness.
The aim of the investigation was to show that computer games can help to identify those who are at risk. In order to validate games analysis was completed which measured the correlations between results of the 'Find the Pairs' memory game and the volumes of the temporal brain regions previously found to be good predictors of later cognitive decline.
34 healthy elderly subjects were enrolled in the study. The volume of the cerebral structures was measured by MRI. Cortical reconstruction and volumetric segmentation were performed by Freesurfer.
There was a correlation between the number of attempts and the time required to complete the memory game and the volume of the entorhinal cortex, the temporal pole, and the hippocampus. There was also a correlation between the results of the Paired Associates Learning (PAL) test and the memory game.
The results gathered support the initial hypothesis that healthy elderly subjects achieving lower scores in the memory game have increased level of atrophy in the temporal brain structures and showed a decreased performance in the PAL test. Based on these results it can be concluded that memory games may be useful in early screening for cognitive decline.
预计当前和未来的预防性治疗在痴呆症早期可能会更有效，此时日常功能尚未受到影响。因此，早期识别有风险的人群尤为重要。在大多数情况下，当受试者拜访专家并接受神经心理测试时，疾病已经发展。与此相反，认知游戏是由健康、功能良好的老年人玩的，这些人应该被监测早期迹象。认知游戏的其他优点是其可及性和成本效益。
该调查的目的是表明电脑游戏有助于识别有风险的人。为了验证游戏，完成了分析，测量了“找对子”记忆游戏结果与先前发现是后期认知衰退良好预测指标的颞脑区域体积之间的相关性。
34名健康老年受试者参与了该研究。通过MRI测量脑结构的体积。由Freesurfer进行皮质重建和体积分割。
完成记忆游戏所需的尝试次数和时间与内嗅皮质、颞极和海马体的体积之间存在相关性。配对联想学习（PAL）测试结果与记忆游戏之间也存在相关性。
收集到的结果支持最初的假设，即在记忆游戏中得分较低的健康老年受试者颞脑结构萎缩水平增加，并且在PAL测试中表现下降。基于这些结果可以得出结论，记忆游戏可能有助于认知衰退的早期筛查。
